Sub-100 nm gold nanomatryoshkas improve photo-thermal therapy efficacy in large and highly aggressive triple negative breast tumors

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dc.citation.firstpage90en_US
dc.citation.journalTitleJournal of Controlled Releaseen_US
dc.citation.lastpage97en_US
dc.citation.volumeNumber191en_US
dc.contributor.authorAyala-Orozco, Ciceronen_US
dc.contributor.authorUrban, Cordulaen_US
dc.contributor.authorBishnoi, Sandraen_US
dc.contributor.authorUrban, Alexanderen_US
dc.contributor.authorCharron, Heatheren_US
dc.contributor.authorMitchell, Tamikaen_US
dc.contributor.authorShea, Martinen_US
dc.contributor.authorNanda, Sarmisthaen_US
dc.contributor.authorSchiff, Rachelen_US
dc.contributor.authorHalas, Naomien_US
dc.contributor.authorJoshi, Amiten_US
dc.date.accessioned2017-06-01T18:53:01Zen_US
dc.date.available2017-06-01T18:53:01Zen_US
dc.date.issued2014en_US
dc.description.abstractThere is an unmet need for efficient near-infrared photothermal transducers for the treatment of highly aggressive cancers and large tumors where the penetration of light can be substantially reduced, and the intra-tumoral nanoparticle transport is restricted due to the presence of hypoxic or necrotic regions. We report the performance advantages obtained by sub 100 nm gold nanomatryushkas, comprising concentric gold–silica–gold layers compared to conventional ~ 150 nm silica core gold nanoshells for photothermal therapy of triple negative breast cancer. We demonstrate that a 33% reduction in silica–core–gold-shell nanoparticle size, while retaining near-infrared plasmon resonance, and keeping the nanoparticle surface charge constant, results in a four to five fold tumor accumulation of nanoparticles following equal dose of injected gold for both sizes. The survival time of mice bearing large (> 1000 mm3) and highly aggressive triple negative breast tumors is doubled for the nanomatryushka treatment group under identical photo-thermal therapy conditions. The higher absorption cross-section of a nanomatryoshka results in a higher efficiency of photonic to thermal energy conversion and coupled with 4–5 × accumulation within large tumors results in superior therapy efficacy.en_US
dc.identifier.citationAyala-Orozco, Ciceron, Urban, Cordula, Bishnoi, Sandra, et al.. "Sub-100 nm gold nanomatryoshkas improve photo-thermal therapy efficacy in large and highly aggressive triple negative breast tumors." <i>Journal of Controlled Release,</i> 191, (2014) Elsevier: 90-97. https://doi.org/10.1016/j.jconrel.2014.07.038.en_US
dc.identifier.doihttps://doi.org/10.1016/j.jconrel.2014.07.038en_US
dc.identifier.urihttps://hdl.handle.net/1911/94759en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordNanomatryoshkaen_US
dc.subject.keywordMultilayer nanoshells Au/SiO2/Auen_US
dc.subject.keywordphotothermal therapyen_US
dc.subject.keywordnear infrareden_US
dc.subject.keywordgold nanoparticleen_US
dc.titleSub-100 nm gold nanomatryoshkas improve photo-thermal therapy efficacy in large and highly aggressive triple negative breast tumorsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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