Modeling mechanical interactions in growing populations of rod-shaped bacteria

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dc.citation.articleNumber055001
dc.citation.issueNumber5
dc.citation.journalTitlePhysical Biology
dc.citation.volumeNumber14
dc.contributor.authorWinkle, James J.
dc.contributor.authorIgoshin, Oleg A.
dc.contributor.authorBennett, Matthew R.
dc.contributor.authorJosić, Krešimir
dc.contributor.authorOtt, William
dc.date.accessioned2017-11-15T14:12:34Z
dc.date.available2017-11-15T14:12:34Z
dc.date.issued2017
dc.description.abstractAdvances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular fluid flow lead to complex, changing arrangements of cells within the population. To rationally engineer and control the behavior of cell collectives we need theoretical and computational tools to understand their emergent spatiotemporal dynamics. Here, we present an agent-based model that allows growing cells to detect and respond to mechanical interactions. Crucially, our model couples the dynamics of cell growth to the cell's environment: Mechanical constraints can affect cellular growth rate and a cell may alter its behavior in response to these constraints. This coupling links the mechanical forces that influence cell growth and emergent behaviors in cell assemblies. We illustrate our approach by showing how mechanical interactions can impact the dynamics of bacterial collectives growing in microfluidic traps.
dc.identifier.citationWinkle, James J., Igoshin, Oleg A., Bennett, Matthew R., et al.. "Modeling mechanical interactions in growing populations of rod-shaped bacteria." <i>Physical Biology,</i> 14, no. 5 (2017) IOP Publishing: https://doi.org/10.1088/1478-3975/aa7bae.
dc.identifier.digitalwinkle_et_al_2017
dc.identifier.doihttps://doi.org/10.1088/1478-3975/aa7bae
dc.identifier.urihttps://hdl.handle.net/1911/98823
dc.language.isoeng
dc.publisherIOP Publishing
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the IOP Press.
dc.titleModeling mechanical interactions in growing populations of rod-shaped bacteria
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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