Modeling mechanical interactions in growing populations of rod-shaped bacteria

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dc.citation.articleNumber055001en_US
dc.citation.issueNumber5en_US
dc.citation.journalTitlePhysical Biologyen_US
dc.citation.volumeNumber14en_US
dc.contributor.authorWinkle, James J.en_US
dc.contributor.authorIgoshin, Oleg A.en_US
dc.contributor.authorBennett, Matthew R.en_US
dc.contributor.authorJosić, Krešimiren_US
dc.contributor.authorOtt, Williamen_US
dc.date.accessioned2017-11-15T14:12:34Zen_US
dc.date.available2017-11-15T14:12:34Zen_US
dc.date.issued2017en_US
dc.description.abstractAdvances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular fluid flow lead to complex, changing arrangements of cells within the population. To rationally engineer and control the behavior of cell collectives we need theoretical and computational tools to understand their emergent spatiotemporal dynamics. Here, we present an agent-based model that allows growing cells to detect and respond to mechanical interactions. Crucially, our model couples the dynamics of cell growth to the cell's environment: Mechanical constraints can affect cellular growth rate and a cell may alter its behavior in response to these constraints. This coupling links the mechanical forces that influence cell growth and emergent behaviors in cell assemblies. We illustrate our approach by showing how mechanical interactions can impact the dynamics of bacterial collectives growing in microfluidic traps.en_US
dc.identifier.citationWinkle, James J., Igoshin, Oleg A., Bennett, Matthew R., et al.. "Modeling mechanical interactions in growing populations of rod-shaped bacteria." <i>Physical Biology,</i> 14, no. 5 (2017) IOP Publishing: https://doi.org/10.1088/1478-3975/aa7bae.en_US
dc.identifier.digitalwinkle_et_al_2017en_US
dc.identifier.doihttps://doi.org/10.1088/1478-3975/aa7baeen_US
dc.identifier.urihttps://hdl.handle.net/1911/98823en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the IOP Press.en_US
dc.titleModeling mechanical interactions in growing populations of rod-shaped bacteriaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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