MR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancers

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dc.citation.articleNumber1909en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitleCancersen_US
dc.citation.volumeNumber14en_US
dc.contributor.authorMulder, Samuel L.en_US
dc.contributor.authorHeukelom, Jolienen_US
dc.contributor.authorMcDonald, Brigid A.en_US
dc.contributor.authorVan Dijk, Lisanneen_US
dc.contributor.authorWahid, Kareem A.en_US
dc.contributor.authorSanders, Keithen_US
dc.contributor.authorSalzillo, Travis C.en_US
dc.contributor.authorHemmati, Mehdien_US
dc.contributor.authorSchaefer, Andrewen_US
dc.contributor.authorFuller, Clifton D.en_US
dc.date.accessioned2022-04-28T14:29:03Zen_US
dc.date.available2022-04-28T14:29:03Zen_US
dc.date.issued2022en_US
dc.description.abstractMR-linac devices offer the potential for advancements in radiotherapy (RT) treatment of head and neck cancer (HNC) by using daily MR imaging performed at the time and setup of treatment delivery. This article aims to present a review of current adaptive RT (ART) methods on MR-Linac devices directed towards the sparing of organs at risk (OAR) and a view of future adaptive techniques seeking to improve the therapeutic ratio. This ratio expresses the relationship between the probability of tumor control and the probability of normal tissue damage and is thus an important conceptual metric of success in the sparing of OARs. Increasing spatial conformity of dose distributions to target volume and OARs is an initial step in achieving therapeutic improvements, followed by the use of imaging and clinical biomarkers to inform the clinical decision-making process in an ART paradigm. Pre-clinical and clinical findings support the incorporation of biomarkers into ART protocols and investment into further research to explore imaging biomarkers by taking advantage of the daily MR imaging workflow. A coherent understanding of this road map for RT in HNC is critical for directing future research efforts related to sparing OARs using image-guided radiotherapy (IGRT).en_US
dc.identifier.citationMulder, Samuel L., Heukelom, Jolien, McDonald, Brigid A., et al.. "MR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancers." <i>Cancers,</i> 14, no. 8 (2022) MDPI: https://doi.org/10.3390/cancers14081909.en_US
dc.identifier.digitalcancers-14-01909en_US
dc.identifier.doihttps://doi.org/10.3390/cancers14081909en_US
dc.identifier.urihttps://hdl.handle.net/1911/112184en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleMR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancersen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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