MR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancers

Simple item page
dc.citation.articleNumber1909
dc.citation.issueNumber8
dc.citation.journalTitleCancers
dc.citation.volumeNumber14
dc.contributor.authorMulder, Samuel L.
dc.contributor.authorHeukelom, Jolien
dc.contributor.authorMcDonald, Brigid A.
dc.contributor.authorVan Dijk, Lisanne
dc.contributor.authorWahid, Kareem A.
dc.contributor.authorSanders, Keith
dc.contributor.authorSalzillo, Travis C.
dc.contributor.authorHemmati, Mehdi
dc.contributor.authorSchaefer, Andrew
dc.contributor.authorFuller, Clifton D.
dc.date.accessioned2022-04-28T14:29:03Z
dc.date.available2022-04-28T14:29:03Z
dc.date.issued2022
dc.description.abstractMR-linac devices offer the potential for advancements in radiotherapy (RT) treatment of head and neck cancer (HNC) by using daily MR imaging performed at the time and setup of treatment delivery. This article aims to present a review of current adaptive RT (ART) methods on MR-Linac devices directed towards the sparing of organs at risk (OAR) and a view of future adaptive techniques seeking to improve the therapeutic ratio. This ratio expresses the relationship between the probability of tumor control and the probability of normal tissue damage and is thus an important conceptual metric of success in the sparing of OARs. Increasing spatial conformity of dose distributions to target volume and OARs is an initial step in achieving therapeutic improvements, followed by the use of imaging and clinical biomarkers to inform the clinical decision-making process in an ART paradigm. Pre-clinical and clinical findings support the incorporation of biomarkers into ART protocols and investment into further research to explore imaging biomarkers by taking advantage of the daily MR imaging workflow. A coherent understanding of this road map for RT in HNC is critical for directing future research efforts related to sparing OARs using image-guided radiotherapy (IGRT).
dc.identifier.citationMulder, Samuel L., Heukelom, Jolien, McDonald, Brigid A., et al.. "MR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancers." <i>Cancers,</i> 14, no. 8 (2022) MDPI: https://doi.org/10.3390/cancers14081909.
dc.identifier.digitalcancers-14-01909
dc.identifier.doihttps://doi.org/10.3390/cancers14081909
dc.identifier.urihttps://hdl.handle.net/1911/112184
dc.language.isoeng
dc.publisherMDPI
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancers
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
cancers-14-01909.pdf
Size:
791.13 KB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
CAAM Publications