Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation

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dc.citation.firstpage2103en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitleACS Nanoen_US
dc.citation.lastpage2112en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorDominguez-Medina, Sergioen_US
dc.contributor.authorKisley, Lydiaen_US
dc.contributor.authorTauzin, Lawrence J.en_US
dc.contributor.authorHoggard, Annelien_US
dc.contributor.authorShuang, Boen_US
dc.contributor.authorIndrasekara, A. Swarnapali D.S.en_US
dc.contributor.authorChen, Sishanen_US
dc.contributor.authorWang, Lin-Yungen_US
dc.contributor.authorDerry, Paul J.en_US
dc.contributor.authorLiopo, Antonen_US
dc.contributor.authorZubarev, Eugene R.en_US
dc.contributor.authorLandes, Christy F.en_US
dc.contributor.authorLink, Stephanen_US
dc.date.accessioned2016-04-05T20:14:03Zen_US
dc.date.available2016-04-05T20:14:03Zen_US
dc.date.issued2016en_US
dc.description.abstractThe response of living systems to nanoparticles is thought to depend on the protein corona, which forms shortly after exposure to physiological fluids and which is linked to a wide array of pathophysiologies. A mechanistic understanding of the dynamic interaction between proteins and nanoparticles and thus the biological fate of nanoparticles and associated proteins is, however, often missing mainly due to the inadequacies in current ensemble experimental approaches. Through the application of a variety of single molecule and single particle spectroscopic techniques in combination with ensemble level characterization tools, we identified different interaction pathways between gold nanorods and bovine serum albumin depending on the protein concentration. Overall, we found that local changes in protein concentration influence everything from cancer cell uptake to nanoparticle stability and even protein secondary structure. We envision that our findings and methods will lead to strategies to control the associated pathophysiology of nanoparticle exposure in vivo.en_US
dc.identifier.citationDominguez-Medina, Sergio, Kisley, Lydia, Tauzin, Lawrence J., et al.. "Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation." <i>ACS Nano,</i> 10, no. 2 (2016) American Chemical Society: 2103-2112. http://dx.doi.org/10.1021/acsnano.5b06439.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/acsnano.5b06439en_US
dc.identifier.urihttps://hdl.handle.net/1911/88853en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.en_US
dc.rights.urihttp://pubs.acs.org/page/policy/authorchoice_termsofuse.htmlen_US
dc.subject.keywordprotein coronaen_US
dc.subject.keywordnanorodsen_US
dc.subject.keywordsuperlocalization microscopyen_US
dc.subject.keywordcorrelation spectroscopyen_US
dc.subject.keywordsurface plasmonen_US
dc.titleAdsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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