Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis

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dc.citation.firstpage3157en_US
dc.citation.issueNumber18en_US
dc.citation.journalTitleThe Journal of Physical Chemistry Lettersen_US
dc.citation.lastpage3161en_US
dc.citation.volumeNumber5en_US
dc.contributor.authorShuang, Boen_US
dc.contributor.authorCooper, Daviden_US
dc.contributor.authorTaylor, J. Nicken_US
dc.contributor.authorKisley, Lydiaen_US
dc.contributor.authorChen, Jixinen_US
dc.contributor.authorWang, Wenxiaoen_US
dc.contributor.authorLi, Chun Biuen_US
dc.contributor.authorKomatsuzaki, Tamikien_US
dc.contributor.authorLandes, Christy F.en_US
dc.contributor.orgRice Quantum Instituteen_US
dc.date.accessioned2016-04-04T21:23:36Zen_US
dc.date.available2016-04-04T21:23:36Zen_US
dc.date.issued2014en_US
dc.description.abstractWe introduce a step transition and state identification (STaSI) method for piecewise constant single-molecule data with a newly derived minimum description length equation as the objective function. We detect the step transitions using the Student’s t test and group the segments into states by hierarchical clustering. The optimum number of states is determined based on the minimum description length equation. This method provides comprehensive, objective analysis of multiple traces requiring few user inputs about the underlying physical models and is faster and more precise in determining the number of states than established and cutting-edge methods for single-molecule data analysis. Perhaps most importantly, the method does not require either time-tagged photon counting or photon counting in general and thus can be applied to a broad range of experimental setups and analytes.en_US
dc.identifier.citationShuang, Bo, Cooper, David, Taylor, J. Nick, et al.. "Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis." <i>The Journal of Physical Chemistry Letters,</i> 5, no. 18 (2014) American Chemical Society: 3157-3161. http://dx.doi.org/10.1021/jz501435p.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/jz501435pen_US
dc.identifier.urihttps://hdl.handle.net/1911/88850en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an open access article published under an ACS AuthorChoiceﾠLicense, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.en_US
dc.rights.urihttp://pubs.acs.org/page/policy/authorchoice_termsofuse.htmlen_US
dc.subject.keywordstep detectionen_US
dc.subject.keywordchange pointen_US
dc.subject.keywordstate identificationen_US
dc.subject.keywordminimum description lengthen_US
dc.subject.keywordpiecewise constant signalen_US
dc.titleFast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysisen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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