Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis

Simple item page
dc.citation.firstpage3157
dc.citation.issueNumber18
dc.citation.journalTitleThe Journal of Physical Chemistry Letters
dc.citation.lastpage3161
dc.citation.volumeNumber5
dc.contributor.authorShuang, Bo
dc.contributor.authorCooper, David
dc.contributor.authorTaylor, J. Nick
dc.contributor.authorKisley, Lydia
dc.contributor.authorChen, Jixin
dc.contributor.authorWang, Wenxiao
dc.contributor.authorLi, Chun Biu
dc.contributor.authorKomatsuzaki, Tamiki
dc.contributor.authorLandes, Christy F.
dc.contributor.orgRice Quantum Institute
dc.date.accessioned2016-04-04T21:23:36Z
dc.date.available2016-04-04T21:23:36Z
dc.date.issued2014
dc.description.abstractWe introduce a step transition and state identification (STaSI) method for piecewise constant single-molecule data with a newly derived minimum description length equation as the objective function. We detect the step transitions using the Student’s t test and group the segments into states by hierarchical clustering. The optimum number of states is determined based on the minimum description length equation. This method provides comprehensive, objective analysis of multiple traces requiring few user inputs about the underlying physical models and is faster and more precise in determining the number of states than established and cutting-edge methods for single-molecule data analysis. Perhaps most importantly, the method does not require either time-tagged photon counting or photon counting in general and thus can be applied to a broad range of experimental setups and analytes.
dc.identifier.citationShuang, Bo, Cooper, David, Taylor, J. Nick, et al.. "Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis." <i>The Journal of Physical Chemistry Letters,</i> 5, no. 18 (2014) American Chemical Society: 3157-3161. http://dx.doi.org/10.1021/jz501435p.
dc.identifier.doihttp://dx.doi.org/10.1021/jz501435p
dc.identifier.urihttps://hdl.handle.net/1911/88850
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an open access article published under an ACS AuthorChoiceﾠLicense, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
dc.rights.urihttp://pubs.acs.org/page/policy/authorchoice_termsofuse.htmlen_US
dc.subject.keywordstep detection
dc.subject.keywordchange point
dc.subject.keywordstate identification
dc.subject.keywordminimum description length
dc.subject.keywordpiecewise constant signal
dc.titleFast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jz501435p.pdf
Size:
1.75 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Chemistry Publications
ECE Publications