Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
Date
2010-01-05
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Abstract
The present disclosure relates to the use of AHSP to stabilize the α subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microorganisms, or animal erythroid cells. This intact rHb may then be used as part of a blood substitute product.
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Utility patent
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Olson, John S. and Weiss, Mitchell J., "Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein." Patent US7642233B2. issued 2010-01-05. Retrieved from https://hdl.handle.net/1911/80007.