Copper-mediated peptide arylation selective for the N-terminus

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dc.citation.firstpage10501en_US
dc.citation.journalTitleChemical Scienceen_US
dc.citation.lastpage10505en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorMiller, Mary K.en_US
dc.contributor.authorWang, Haopeien_US
dc.contributor.authorHanaya, Kengoen_US
dc.contributor.authorZhang, Oliviaen_US
dc.contributor.authorBerlaga, Alexen_US
dc.contributor.authorBall, Zachary T.en_US
dc.date.accessioned2020-11-06T02:02:48Zen_US
dc.date.available2020-11-06T02:02:48Zen_US
dc.date.issued2020en_US
dc.description.abstractPolypeptides present remarkable selectivity challenges for chemical methods. Amino groups are ubiquitous in polypeptide structure, yet few paradigms exist for reactivity and selectivity in arylation of amine groups. This communication describes the utilization of boronic acid reagents bearing certain o-electron withdrawing groups for copper-mediated amine arylation of the N-terminus under mild conditions and primarily aqueous solvent. The method adds to the toolkit of boronic acid reagents for polypeptide modification under mild conditions in water that shows complete selectivity for the N-terminus in the presence of lysine side chains.en_US
dc.identifier.citationMiller, Mary K., Wang, Haopei, Hanaya, Kengo, et al.. "Copper-mediated peptide arylation selective for the N-terminus." <i>Chemical Science,</i> 11, (2020) Royal Society of Chemistry: 10501-10505. https://doi.org/10.1039/D0SC02933E.en_US
dc.identifier.doihttps://doi.org/10.1039/D0SC02933Een_US
dc.identifier.urihttps://hdl.handle.net/1911/109518en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 3.0 Unported License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/en_US
dc.titleCopper-mediated peptide arylation selective for the N-terminusen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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