Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response
| dc.citation.firstpage | 804 | |
| dc.citation.issueNumber | 1 | |
| dc.citation.journalTitle | Virulence | |
| dc.citation.lastpage | 817 | |
| dc.citation.volumeNumber | 9 | |
| dc.contributor.author | Kang, Donghoon | |
| dc.contributor.author | Kirienko, Daniel R. | |
| dc.contributor.author | Webster, Phillip | |
| dc.contributor.author | Fisher, Alfred L. | |
| dc.contributor.author | Kirienko, Natalia V. | |
| dc.date.accessioned | 2018-08-17T13:36:22Z | |
| dc.date.available | 2018-08-17T13:36:22Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions. | |
| dc.identifier.citation | Kang, Donghoon, Kirienko, Daniel R., Webster, Phillip, et al.. "Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response." <i>Virulence,</i> 9, no. 1 (2018) Taylor & Francis: 804-817. https://doi.org/10.1080/21505594.2018.1449508. | |
| dc.identifier.digital | Pyoverdine | |
| dc.identifier.doi | https://doi.org/10.1080/21505594.2018.1449508 | |
| dc.identifier.uri | https://hdl.handle.net/1911/102464 | |
| dc.language.iso | eng | |
| dc.publisher | Taylor & Francis | |
| dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject.keyword | Caenorhabditis elegans | |
| dc.subject.keyword | Pseudomonas aeruginosa | |
| dc.subject.keyword | host response | |
| dc.subject.keyword | mitochondrial damage | |
| dc.subject.keyword | pathogenesis | |
| dc.subject.keyword | pyoverdine | |
| dc.subject.keyword | siderophore | |
| dc.title | Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response | |
| dc.type | Journal article | |
| dc.type.dcmi | Text | |
| dc.type.publication | publisher version |
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