Measuring the Grafting Density of Nanoparticles in Solution by Analytical Ultracentrifugation and Total Organic Carbon Analysis

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dc.citation.firstpage9238en_US
dc.citation.issueNumber21en_US
dc.citation.journalTitleAnalytical Chemistryen_US
dc.citation.lastpage9245en_US
dc.citation.volumeNumber84en_US
dc.contributor.authorBenoit, Denise N.en_US
dc.contributor.authorZhu, Huiguangen_US
dc.contributor.authorLilierose, Michael H.en_US
dc.contributor.authorVerm, Raymond A.en_US
dc.contributor.authorAli, Naushabaen_US
dc.contributor.authorMorrison, Adam N.en_US
dc.contributor.authorFortner, John D.en_US
dc.contributor.authorAvendano, Carolinaen_US
dc.contributor.authorColvin, Vicki L.en_US
dc.date.accessioned2017-08-02T14:52:15Zen_US
dc.date.available2017-08-02T14:52:15Zen_US
dc.date.issued2012en_US
dc.description.abstractMany of the solution phase properties of nanoparticles, such as their colloidal stability and hydrodynamic diameter, are governed by the number of stabilizing groups bound to the particle surface (i.e., grafting density). Here, we show how two techniques, analytical ultracentrifugation (AUC) and total organic carbon analysis (TOC), can be applied separately to the measurement of this parameter. AUC directly measures the density of nanoparticle–polymer conjugates while TOC provides the total carbon content of its aqueous dispersions. When these techniques are applied to model gold nanoparticles capped with thiolated poly(ethylene glycol), the measured grafting densities across a range of polymer chain lengths, polymer concentrations, and nanoparticle diameters agree to within 20%. Moreover, the measured grafting densities correlate well with the polymer content determined by thermogravimetric analysis of solid conjugate samples. Using these tools, we examine the particle core diameter, polymer chain length, and polymer solution concentration dependence of nanoparticle grafting densities in a gold nanoparticle–poly(ethylene glycol) conjugate system.en_US
dc.identifier.citationBenoit, Denise N., Zhu, Huiguang, Lilierose, Michael H., et al.. "Measuring the Grafting Density of Nanoparticles in Solution by Analytical Ultracentrifugation and Total Organic Carbon Analysis." <i>Analytical Chemistry,</i> 84, no. 21 (2012) American Chemical Society: 9238-9245. https://doi.org/10.1021/ac301980a.en_US
dc.identifier.digitalMeasuring_Grafting_Densityen_US
dc.identifier.doihttps://doi.org/10.1021/ac301980aen_US
dc.identifier.urihttps://hdl.handle.net/1911/96164en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.titleMeasuring the Grafting Density of Nanoparticles in Solution by Analytical Ultracentrifugation and Total Organic Carbon Analysisen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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