Hyaluronan: A simple polysaccharide with diverse biological functions

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dc.citation.firstpage1558en_US
dc.citation.issueNumber4en_US
dc.citation.journalTitleActa Biomaterialiaen_US
dc.citation.lastpage1570en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorDicker, Kevin T.en_US
dc.contributor.authorGurski, Lisa A.en_US
dc.contributor.authorPradhan-Bhatt, Swatien_US
dc.contributor.authorWitt, Robert L.en_US
dc.contributor.authorFarach-Carson, Mary C.en_US
dc.contributor.authorJia, Xinqiaoen_US
dc.date.accessioned2017-08-17T19:19:41Zen_US
dc.date.available2017-08-17T19:19:41Zen_US
dc.date.issued2014en_US
dc.description.abstractHyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the extracellular matrix (ECM), on the cell surface and even inside cells. Being a simple polysaccharide, HA exhibits an astonishing array of biological functions. HA interacts with various proteins or proteoglycans to organize the ECM and to maintain tissue homeostasis. The unique physical and mechanical properties of HA contribute to the maintenance of tissue hydration, the mediation of solute diffusion through the extracellular space and the lubrication of certain tissues. The diverse biological functions of HA are manifested through its complex interactions with matrix components and resident cells. Binding of HA with cell surface receptors activates various signaling pathways, which regulate cell function, tissue development, inflammation, wound healing and tumor progression and metastasis. Taking advantage of the inherent biocompatibility and biodegradability of HA, as well as its susceptibility to chemical modification, researchers have developed various HA-based biomaterials and tissue constructs with promising and broad clinical potential. This paper illustrates the properties of HA from a matrix biology perspective by first introducing the principles underlying the biosynthesis and biodegradation of HA, as well as the interactions of HA with various proteins and proteoglycans. It next highlights the roles of HA in physiological and pathological states, including morphogenesis, wound healing and tumor metastasis. A deeper understanding of the mechanisms underlying the roles of HA in various physiological processes can provide new insights and tools for the engineering of complex tissues and tissue models.en_US
dc.identifier.citationDicker, Kevin T., Gurski, Lisa A., Pradhan-Bhatt, Swati, et al.. "Hyaluronan: A simple polysaccharide with diverse biological functions." <i>Acta Biomaterialia,</i> 10, no. 4 (2014) Elsevier: 1558-1570. https://doi.org/10.1016/j.actbio.2013.12.019.en_US
dc.identifier.digitalHyaluronanen_US
dc.identifier.doihttps://doi.org/10.1016/j.actbio.2013.12.019en_US
dc.identifier.urihttps://hdl.handle.net/1911/97337en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordHyaluronanen_US
dc.subject.keywordSynthaseen_US
dc.subject.keywordHyaluronidaseen_US
dc.subject.keywordHyaluronan Receptorsen_US
dc.subject.keywordHyaluronan Binding Proteinsen_US
dc.subject.keywordMorphogenesisen_US
dc.subject.keywordWound Healingen_US
dc.subject.keywordCanceren_US
dc.subject.keywordTissue Engineeringen_US
dc.titleHyaluronan: A simple polysaccharide with diverse biological functionsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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