Noradrenaline tracks emotional modulation of attention in human amygdala

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dc.citation.firstpage5003en_US
dc.citation.issueNumber22en_US
dc.citation.journalTitleCurrent Biologyen_US
dc.citation.lastpage5010.e6en_US
dc.citation.volumeNumber33en_US
dc.contributor.authorBang, Danen_US
dc.contributor.authorLuo, Yien_US
dc.contributor.authorBarbosa, Leonardo S.en_US
dc.contributor.authorBatten, Seth R.en_US
dc.contributor.authorHadj-Amar, Beniaminoen_US
dc.contributor.authorTwomey, Thomasen_US
dc.contributor.authorMelville, Natalieen_US
dc.contributor.authorWhite, Jason P.en_US
dc.contributor.authorTorres, Alexisen_US
dc.contributor.authorCelaya, Xavieren_US
dc.contributor.authorRamaiah, Priyaen_US
dc.contributor.authorMcClure, Samuel M.en_US
dc.contributor.authorBrewer, Gene A.en_US
dc.contributor.authorBina, Robert W.en_US
dc.contributor.authorLohrenz, Terryen_US
dc.contributor.authorCasas, Brooksen_US
dc.contributor.authorChiu, Pearl H.en_US
dc.contributor.authorVannucci, Marinaen_US
dc.contributor.authorKishida, Kenneth T.en_US
dc.contributor.authorWitcher, Mark R.en_US
dc.contributor.authorMontague, P. Readen_US
dc.date.accessioned2024-05-08T18:56:08Zen_US
dc.date.available2024-05-08T18:56:08Zen_US
dc.date.issued2023en_US
dc.description.abstractThe noradrenaline (NA) system is one of the brain’s major neuromodulatory systems; it originates in a small midbrain nucleus, the locus coeruleus (LC), and projects widely throughout the brain.1,2 The LC-NA system is believed to regulate arousal and attention3,4 and is a pharmacological target in multiple clinical conditions.5,6,7 Yet our understanding of its role in health and disease has been impeded by a lack of direct recordings in humans. Here, we address this problem by showing that electrochemical estimates of sub-second NA dynamics can be obtained using clinical depth electrodes implanted for epilepsy monitoring. We made these recordings in the amygdala, an evolutionarily ancient structure that supports emotional processing8,9 and receives dense LC-NA projections,10 while patients (n = 3) performed a visual affective oddball task. The task was designed to induce different cognitive states, with the oddball stimuli involving emotionally evocative images,11 which varied in terms of arousal (low versus high) and valence (negative versus positive). Consistent with theory, the NA estimates tracked the emotional modulation of attention, with a stronger oddball response in a high-arousal state. Parallel estimates of pupil dilation, a common behavioral proxy for LC-NA activity,12 supported a hypothesis that pupil-NA coupling changes with cognitive state,13,14 with the pupil and NA estimates being positively correlated for oddball stimuli in a high-arousal but not a low-arousal state. Our study provides proof of concept that neuromodulator monitoring is now possible using depth electrodes in standard clinical use.en_US
dc.identifier.citationBang, D., Luo, Y., Barbosa, L. S., Batten, S. R., Hadj-Amar, B., Twomey, T., Melville, N., White, J. P., Torres, A., Celaya, X., Ramaiah, P., McClure, S. M., Brewer, G. A., Bina, R. W., Lohrenz, T., Casas, B., Chiu, P. H., Vannucci, M., Kishida, K. T., … Montague, P. R. (2023). Noradrenaline tracks emotional modulation of attention in human amygdala. Current Biology, 33(22), 5003-5010.e6. https://doi.org/10.1016/j.cub.2023.09.074en_US
dc.identifier.digital1-s20-S0960982223013556-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.cub.2023.09.074en_US
dc.identifier.urihttps://hdl.handle.net/1911/115652en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleNoradrenaline tracks emotional modulation of attention in human amygdalaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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