Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses

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dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorHo, Michelleen_US
dc.creatorSuh, Junghaeen_US
dc.creatorYamagami, Momonaen_US
dc.creatorGough, Veronicaen_US
dc.creatorKang, Byunguken_US
dc.date.accessioned2021-03-02T23:26:23Zen_US
dc.date.available2021-03-02T23:26:23Zen_US
dc.date.filed2018-04-16en_US
dc.date.issued2020-12-08en_US
dc.description.abstractThe present disclosure provide viral compositions and methods for modulating adeno-associated virus properties including transduction efficiency, virus capsid assembly, viral genome packaging, capsid stability and intracellular processing. Engineered adeno-associated viruses with modifications in the N-terminal region of the capsid proteins VP1 or VP2 are provided which have varying effects on viral properties including transduction efficiency. Corresponding nucleic acids and amino acids are provided.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposesen_US
dc.format.extent95en_US
dc.identifier.citationHo, Michelle, Suh, Junghae, Yamagami, Momona, Gough, Veronica and Kang, Byunguk, "Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses." Patent US10858630B2. issued 2020-12-08. Retrieved from <a href="https://hdl.handle.net/1911/110125">https://hdl.handle.net/1911/110125</a>.en_US
dc.identifier.patentIDUS10858630B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/110125en_US
dc.language.isoengen_US
dc.titleModification of n-terminal region of capsid proteins for enhanced properties of adeno-associated virusesen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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