Structure-Property Evaluation of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering

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dc.citation.firstpage2821en_US
dc.citation.issueNumber9en_US
dc.citation.journalTitleBiomacromoleculesen_US
dc.citation.lastpage2830en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorEkenseair, Adam K.en_US
dc.contributor.authorBoere, Kristel W.M.en_US
dc.contributor.authorTzouanas, Stephanie N.en_US
dc.contributor.authorVo, Tiffany N.en_US
dc.contributor.authorKasper, F. Kurtisen_US
dc.contributor.authorMikos, Antonios G.en_US
dc.date.accessioned2015-01-06T15:49:12Zen_US
dc.date.available2015-01-06T15:49:12Zen_US
dc.date.issued2012en_US
dc.description.abstractThe impact of synthesis and solution formulation parameters on the swelling and mechanical properties of a novel class of thermally and chemically gelling hydrogels combining poly(N-isopropylacrylamide)-based thermogelling macromers containing pendant epoxy rings with polyamidoamine-based hydrophilic and degradable diamine cross-linking macromers was evaluated. Through variation of network hydrophilicity and capacity for chain rearrangement, the often problematic tendency of thermogelling hydrogels to undergo significant syneresis was addressed. The demonstrated ability to tune postformation dimensional stability easily at both the synthesis and formulation stages represents a significant novel contribution toward efforts to utilize poly(N-isopropylacrylamide)-based polymers as injectable biomaterials. Furthermore, the cytocompatibility of the hydrogel system under relevant conditions was established while demonstrating time- and dose-dependent cytotoxicity at high solution osmolality. Such injectable in situ forming degradable hydrogels with tunable water content are promising candidates for many tissue-engineering applications, particularly for cell delivery to promote rapid tissue regeneration in non-load-bearing defects.en_US
dc.identifier.citationEkenseair, Adam K., Boere, Kristel W.M., Tzouanas, Stephanie N., et al.. "Structure-Property Evaluation of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering." <i>Biomacromolecules,</i> 13, no. 9 (2012) American Chemical Society: 2821-2830. http://dx.doi.org/10.1021/bm300797m.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/bm300797men_US
dc.identifier.urihttps://hdl.handle.net/1911/78881en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordpoly(N-isopropylacrylamide)en_US
dc.subject.keywordpolyamidoamineen_US
dc.subject.keywordtissue engineeringen_US
dc.subject.keywordinjectableen_US
dc.subject.keywordhydrogelen_US
dc.titleStructure-Property Evaluation of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineeringen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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