Phenomenological modeling of durotaxis

Simple item page
dc.citation.articleNumber010402(R)
dc.citation.issueNumber1
dc.citation.journalTitlePhysical Review E
dc.citation.volumeNumber96
dc.contributor.authorYu, Guangyuan
dc.contributor.authorFeng, Jingchen
dc.contributor.authorMan, Haoran
dc.contributor.authorLevine, Herbert
dc.date.accessioned2017-08-09T17:13:27Z
dc.date.available2017-08-09T17:13:27Z
dc.date.issued2017
dc.description.abstractCells exhibit qualitatively different behaviors on substrates with different rigidities. The fact that cells are more polarized on the stiffer substrate motivates us to construct a two-dimensional cell with the distribution of focal adhesions dependent on substrate rigidities. This distribution affects the forces exerted by the cell and thereby determines its motion. Our model reproduces the experimental observation that the persistence time is higher on the stiffer substrate. This stiffness-dependent persistence will lead to durotaxis, the preference in moving towards stiffer substrates. This propensity is characterized by the durotaxis index first defined in experiments. We derive and validate a two-dimensional corresponding Fokker-Planck equation associated with our model. Our approach highlights the possible role of the focal adhesion arrangement in durotaxis.
dc.identifier.citationYu, Guangyuan, Feng, Jingchen, Man, Haoran, et al.. "Phenomenological modeling of durotaxis." <i>Physical Review E,</i> 96, no. 1 (2017) American Physical Society: https://doi.org/10.1103/PhysRevE.96.010402.
dc.identifier.digitalPhenomenological_modeling_durotaxis
dc.identifier.doihttps://doi.org/10.1103/PhysRevE.96.010402
dc.identifier.urihttps://hdl.handle.net/1911/96637
dc.language.isoeng
dc.publisherAmerican Physical Society
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titlePhenomenological modeling of durotaxis
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
modeling_durotaxis.pdf
Size:
3.96 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications