Carbon Nano-Onions Reinforced Multilayered Thin Film System for Stimuli-Responsive Drug Release

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dc.citation.articleNumber1208en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitlePharmaceuticsen_US
dc.citation.volumeNumber12en_US
dc.contributor.authorMamidi, Narsimhaen_US
dc.contributor.authorVelasco Delgadillo, Ramiro Manuelen_US
dc.contributor.authorGonzáles Ortiz, Aldoen_US
dc.contributor.authorBarrera, Enrique V.en_US
dc.date.accessioned2021-02-08T18:37:59Zen_US
dc.date.available2021-02-08T18:37:59Zen_US
dc.date.issued2020en_US
dc.description.abstractHerein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs) and anilinated-poly (ether ether ketone) (AN-PEEK) have synthesized, and AN-PEEK/f-CNOs composite thin films were primed via layer-by-layer (LbL) self-assembly for stimuli-responsive drug release. The obtained thin films exhibited pH-responsive drug release in a controlled manner; pH 4.5 = 99.2% and pH 6.5 = 59.3% of doxorubicin (DOX) release was observed over 15 days. Supramolecular π-π stacking interactions between f-CNOs and DOX played a critical role in controlling drug release from thin films. Cell viability was studied with human osteoblast cells and augmented viability was perceived. Moreover, the thin films presented 891.4 ± 8.2 MPa of the tensile strength (σult), 43.2 ± 1.1 GPa of Young’s modulus (E), and 164.5 ± 1.7 Jg−1 of toughness (K). Quantitative scrutiny revealed that the well-ordered aligned nanofibers provide critical interphase, and this could be responsible for augmented tensile properties. Nonetheless, a pH-responsive and mechanically robust biocompatible thin-film system may show potential applications in the biomedical field.en_US
dc.identifier.citationMamidi, Narsimha, Velasco Delgadillo, Ramiro Manuel, Gonzáles Ortiz, Aldo, et al.. "Carbon Nano-Onions Reinforced Multilayered Thin Film System for Stimuli-Responsive Drug Release." <i>Pharmaceutics,</i> 12, no. 12 (2020) MDPI: https://doi.org/10.3390/pharmaceutics12121208.en_US
dc.identifier.digitalpharmaceutics-12-01208-v2en_US
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics12121208en_US
dc.identifier.urihttps://hdl.handle.net/1911/109823en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordnanocomposite thin filmsen_US
dc.subject.keywordlayer-by-layer assemblyen_US
dc.subject.keywordstrengthen_US
dc.subject.keywordYoung’s modulusen_US
dc.subject.keywordtoughnessen_US
dc.subject.keywordpH-responsive drug releaseen_US
dc.subject.keywordcell viabilityen_US
dc.titleCarbon Nano-Onions Reinforced Multilayered Thin Film System for Stimuli-Responsive Drug Releaseen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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