Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications

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dc.citation.journalTitleTissue Engineering Part B: Reviewsen_US
dc.contributor.authorPetsche, Jennifer J.en_US
dc.contributor.authorCamci-Unal, Guldenen_US
dc.contributor.authorKhademhosseini, Alien_US
dc.contributor.authorJacot, Jeffrey G.en_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2013-03-18T20:46:39Zen_US
dc.date.available2013-03-18T20:46:39Zen_US
dc.date.issued2013en_US
dc.description.abstractRecent research has demonstrated that a population of stem cells can be isolated from amniotic fluid removed by amniocentesis that are broadly multipotent and non-tumorogenic. These amniotic fluid-derived stem cells (AFSC) could potentially provide an autologous cell source for treatment of congenital defects identified during gestation, particularly cardiovascular defects. In this review, the various methods of isolating, sorting and culturing AFSC are compared, along with techniques for inducing differentiation into cardiac myocytes and endothelial cells. Though research has not demonstrated complete and high yield cardiac differentiation, AFSC have been shown to effectively differentiate into endothelial cells and can effectively support cardiac tissue. Additionally, several tissue engineering and regenerative therapeutic approaches for the use of these cells in heart patches, injection after myocardial infarction, heart valves, vascularized scaffolds and blood vessels are summarized. These applications show great promise in the treatment of congenital cardiovascular defects, and further studies of isolation, culture, and differentiation of AFSC will help to develop their use for tissue engineering, regenerative medicine, and cardiovascular therapies.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationPetsche, Jennifer J., Camci-Unal, Gulden, Khademhosseini, Ali, et al.. "Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications." <i>Tissue Engineering Part B: Reviews,</i> (2013) Mary Ann Liebert, Inc.: http://dx.doi.org/10.1089/ten.TEB.2012.0561.en_US
dc.identifier.doihttp://dx.doi.org/10.1089/ten.TEB.2012.0561en_US
dc.identifier.urihttps://hdl.handle.net/1911/70702en_US
dc.language.isoengen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Mary Ann Liebert, Inc.en_US
dc.titleAmniotic fluid-derived stem cells for cardiovascular tissue engineering applicationsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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