NF-κB and IRF pathways: cross-regulation on target genes promoter level

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dc.citation.journalTitleBMC Genomicsen_US
dc.citation.volumeNumber16en_US
dc.contributor.authorIwanaszko, Martaen_US
dc.contributor.authorKimmel, Mareken_US
dc.date.accessioned2015-06-30T16:22:57Zen_US
dc.date.available2015-06-30T16:22:57Zen_US
dc.date.issued2015en_US
dc.description.abstractBackground: The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). The regulatory mechanisms of activation of these two pathways and their interactions during the IIR are only partially known. Results: Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. These findings agree with recent experimental data reporting crosstalk between pathways activated by RIG-I and TLR3 receptors in response to pathogens. Conclusions: We present an extended crosstalk diagram of the IRF - NF-κB pathways. We conclude that members of the NF-κB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-κB family rather indirectly, via other transcription factors such as AP-1 and SP1.en_US
dc.identifier.citationIwanaszko, Marta and Kimmel, Marek. "NF-κB and IRF pathways: cross-regulation on target genes promoter level." <i>BMC Genomics,</i> 16, (2015) BioMed Central Ltd: http://dx.doi.org/10.1186/s12864-015-1511-7.en_US
dc.identifier.doihttp://dx.doi.org/10.1186/s12864-015-1511-7en_US
dc.identifier.urihttps://hdl.handle.net/1911/80843en_US
dc.language.isoengen_US
dc.publisherBioMed Central Ltden_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordNF-κBen_US
dc.subject.keywordIRF3en_US
dc.subject.keywordtranscription factorsen_US
dc.subject.keywordcrosstalken_US
dc.subject.keywordinnate immune responseen_US
dc.titleNF-κB and IRF pathways: cross-regulation on target genes promoter levelen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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