Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

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dc.citation.articleNumber7019en_US
dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber14en_US
dc.contributor.authorLee, Inkyuen_US
dc.contributor.authorSurendran, Abhijithen_US
dc.contributor.authorFleury, Samanthaen_US
dc.contributor.authorGimino, Ianen_US
dc.contributor.authorCurtiss, Alexanderen_US
dc.contributor.authorFell, Codyen_US
dc.contributor.authorShiwarski, Daniel J.en_US
dc.contributor.authorRefy, Omaren_US
dc.contributor.authorRothrock, Blaineen_US
dc.contributor.authorJo, Seonghanen_US
dc.contributor.authorSchwartzkopff, Timen_US
dc.contributor.authorMehta, Abijeet Singhen_US
dc.contributor.authorWang, Yingqiaoen_US
dc.contributor.authorSipe, Adamen_US
dc.contributor.authorJohn, Sharonen_US
dc.contributor.authorJi, Xudongen_US
dc.contributor.authorNikiforidis, Georgiosen_US
dc.contributor.authorFeinberg, Adam W.en_US
dc.contributor.authorHester, Josiahen_US
dc.contributor.authorWeber, Douglas J.en_US
dc.contributor.authorVeiseh, Omiden_US
dc.contributor.authorRivnay, Jonathanen_US
dc.contributor.authorCohen-Karni, Tzahien_US
dc.date.accessioned2024-05-03T15:51:18Zen_US
dc.date.available2024-05-03T15:51:18Zen_US
dc.date.issued2023en_US
dc.description.abstractImplantable cell therapies and tissue transplants require sufficient oxygen supply to function and are limited by a delay or lack of vascularization from the transplant host. Previous exogenous oxygenation strategies have been bulky and had limited oxygen production or regulation. Here, we show an electrocatalytic approach that enables bioelectronic control of oxygen generation in complex cellular environments to sustain engineered cell viability and therapy under hypoxic stress and at high cell densities. We find that nanostructured sputtered iridium oxide serves as an ideal catalyst for oxygen evolution reaction at neutral pH. We demonstrate that this approach exhibits a lower oxygenation onset and selective oxygen production without evolution of toxic byproducts. We show that this electrocatalytic on site oxygenator can sustain high cell loadings (>60k cells/mm3) in hypoxic conditions in vitro and in vivo. Our results showcase that exogenous oxygen production devices can be readily integrated into bioelectronic platforms, enabling high cell loadings in smaller devices with broad applicability.en_US
dc.identifier.citationLee, I., Surendran, A., Fleury, S., Gimino, I., Curtiss, A., Fell, C., Shiwarski, D. J., Refy, O., Rothrock, B., Jo, S., Schwartzkopff, T., Mehta, A. S., Wang, Y., Sipe, A., John, S., Ji, X., Nikiforidis, G., Feinberg, A. W., Hester, J., … Cohen-Karni, T. (2023). Electrocatalytic on-site oxygenation for transplanted cell-based-therapies. Nature Communications, 14(1), 7019. https://doi.org/10.1038/s41467-023-42697-2en_US
dc.identifier.digitals41467-023-42697-2en_US
dc.identifier.doihttps://doi.org/10.1038/s41467-023-42697-2en_US
dc.identifier.urihttps://hdl.handle.net/1911/115613en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleElectrocatalytic on-site oxygenation for transplanted cell-based-therapiesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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