Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes

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dc.citation.articleNumber112554en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleCell Reportsen_US
dc.citation.volumeNumber42en_US
dc.contributor.authorLycke, Royen_US
dc.contributor.authorKim, Robinen_US
dc.contributor.authorZolotavin, Pavloen_US
dc.contributor.authorMontes, Jonen_US
dc.contributor.authorSun, Yingchuen_US
dc.contributor.authorKoszeghy, Aronen_US
dc.contributor.authorAltun, Esraen_US
dc.contributor.authorNoble, Brianen_US
dc.contributor.authorYin, Rongkangen_US
dc.contributor.authorHe, Feien_US
dc.contributor.authorTotah, Nelsonen_US
dc.contributor.authorXie, Chongen_US
dc.contributor.authorLuan, Lanen_US
dc.contributor.orgRice Neuroengineering Initiativeen_US
dc.date.accessioned2023-07-21T16:13:32Zen_US
dc.date.available2023-07-21T16:13:32Zen_US
dc.date.issued2023en_US
dc.description.abstractIntracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation are often compromised by adverse tissue responses to the indwelling electrodes. Here we engineer ultraflexible stim-nanoelectronic threads (StimNETs) and demonstrate low activation threshold, high resolution, and chronically stable ICMS in awake, behaving mouse models. In vivo two-photon imaging reveals that StimNETs remain seamlessly integrated with the nervous tissue throughout chronic stimulation periods and elicit stable, focal neuronal activation at low currents of 2 μA. Importantly, StimNETs evoke longitudinally stable behavioral responses for over 8 months at a markedly low charge injection of 0.25 nC/phase. Quantified histological analyses show that chronic ICMS by StimNETs induces no neuronal degeneration or glial scarring. These results suggest that tissue-integrated electrodes provide a path for robust, long-lasting, spatially selective neuromodulation at low currents, which lessens risk of tissue damage or exacerbation of off-target side effects.en_US
dc.identifier.citationLycke, Roy, Kim, Robin, Zolotavin, Pavlo, et al.. "Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes." <i>Cell Reports,</i> 42, no. 6 (2023) Cell Press: https://doi.org/10.1016/j.celrep.2023.112554.en_US
dc.identifier.digital1-s2-0-S221112472300565X-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2023.112554en_US
dc.identifier.urihttps://hdl.handle.net/1911/114963en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleLow-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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