Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes

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dc.citation.articleNumber112554
dc.citation.issueNumber6
dc.citation.journalTitleCell Reports
dc.citation.volumeNumber42
dc.contributor.authorLycke, Roy
dc.contributor.authorKim, Robin
dc.contributor.authorZolotavin, Pavlo
dc.contributor.authorMontes, Jon
dc.contributor.authorSun, Yingchu
dc.contributor.authorKoszeghy, Aron
dc.contributor.authorAltun, Esra
dc.contributor.authorNoble, Brian
dc.contributor.authorYin, Rongkang
dc.contributor.authorHe, Fei
dc.contributor.authorTotah, Nelson
dc.contributor.authorXie, Chong
dc.contributor.authorLuan, Lan
dc.contributor.orgRice Neuroengineering Initiative
dc.date.accessioned2023-07-21T16:13:32Z
dc.date.available2023-07-21T16:13:32Z
dc.date.issued2023
dc.description.abstractIntracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation are often compromised by adverse tissue responses to the indwelling electrodes. Here we engineer ultraflexible stim-nanoelectronic threads (StimNETs) and demonstrate low activation threshold, high resolution, and chronically stable ICMS in awake, behaving mouse models. In vivo two-photon imaging reveals that StimNETs remain seamlessly integrated with the nervous tissue throughout chronic stimulation periods and elicit stable, focal neuronal activation at low currents of 2 μA. Importantly, StimNETs evoke longitudinally stable behavioral responses for over 8 months at a markedly low charge injection of 0.25 nC/phase. Quantified histological analyses show that chronic ICMS by StimNETs induces no neuronal degeneration or glial scarring. These results suggest that tissue-integrated electrodes provide a path for robust, long-lasting, spatially selective neuromodulation at low currents, which lessens risk of tissue damage or exacerbation of off-target side effects.
dc.identifier.citationLycke, Roy, Kim, Robin, Zolotavin, Pavlo, et al.. "Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes." <i>Cell Reports,</i> 42, no. 6 (2023) Cell Press: https://doi.org/10.1016/j.celrep.2023.112554.
dc.identifier.digital1-s2-0-S221112472300565X-main
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2023.112554
dc.identifier.urihttps://hdl.handle.net/1911/114963
dc.language.isoeng
dc.publisherCell Press
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLow-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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