Evaluation of a Point-of-Care Test for Bilirubin in Malawi

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dc.citation.articleNumbere2021053928
dc.citation.issueNumber2
dc.citation.journalTitlePediatrics
dc.citation.volumeNumber150
dc.contributor.authorShapiro, Alyssa
dc.contributor.authorAnderson, Jessica
dc.contributor.authorMtenthaonga, Prince
dc.contributor.authorKumwenda, Watson
dc.contributor.authorBond, Meaghan
dc.contributor.authorSchwarz, Richard
dc.contributor.authorCarns, Jennifer
dc.contributor.authorJohnston, Ryan
dc.contributor.authorDube, Queen
dc.contributor.authorChiume, Msandeni
dc.contributor.authorRichards-Kortum, Rebecca
dc.contributor.orgRice 360° Institute for Global Health
dc.date.accessioned2022-09-01T14:18:22Z
dc.date.available2022-09-01T14:18:22Z
dc.date.issued2022
dc.description.abstractOBJECTIVES: BiliSpec is a low-cost spectrophotometric reader and disposable paper-based strip to quantify total serum bilirubin from several blood drops. This study was a prospective evaluation of BiliSpec in 2 neonatal wards in Malawi compared with a reference standard bilirubinometer over a large range of bilirubin and hematocrit levels. METHODS: The accuracy of BiliSpec and a transcutaneous bilirubinometer were compared with the reference standard of spectrophotometry for 475 blood samples collected from 375 subjects across a range of total serum bilirubin concentrations from 0.0 to 33.7 mg/dL. The development of error grids to assess the clinical effects of measurement differences is reported. RESULTS: BiliSpec was found to have a mean bias of −0.48 mg/dL and 95% limits of agreement of −5.09 mg/dL to +4.12 mg/dL. Results show 90.7% of BiliSpec measurements would have resulted in the same clinical decision as the reference standard, whereas 55.0% of transcutaneous bilirubin measurements would have resulted in the same clinical decision as the reference standard. CONCLUSIONS: This evaluation supports use of BiliSpec to provide accurate, low-cost, point-of-care bilirubin measurements in low-resource hospitals. Future work is needed to evaluate BiliSpec among a larger number of users.
dc.identifier.citationShapiro, Alyssa, Anderson, Jessica, Mtenthaonga, Prince, et al.. "Evaluation of a Point-of-Care Test for Bilirubin in Malawi." <i>Pediatrics,</i> 150, no. 2 (2022) American Academy of Pediatrics: https://doi.org/10.1542/peds.2021-053928.
dc.identifier.digitalpeds_2021053928
dc.identifier.doihttps://doi.org/10.1542/peds.2021-053928
dc.identifier.urihttps://hdl.handle.net/1911/113169
dc.language.isoeng
dc.publisherAmerican Academy of Pediatrics
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License .
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEvaluation of a Point-of-Care Test for Bilirubin in Malawi
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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