Autologously Generated Tissue-Engineered Bone Flaps for Reconstruction of Large Mandibular Defects in an Ovine Model

Simple item page
dc.citation.firstpage1520en_US
dc.citation.issueNumber10-Sepen_US
dc.citation.journalTitleTissue Engineering Part Aen_US
dc.citation.lastpage1528en_US
dc.citation.volumeNumber21en_US
dc.contributor.authorTatara, Alexander M.en_US
dc.contributor.authorKretlow, James D.en_US
dc.contributor.authorSpicer, Patrick P.en_US
dc.contributor.authorLu, Stevenen_US
dc.contributor.authorLam, Johnnyen_US
dc.contributor.authorLiu, Weien_US
dc.contributor.authorCao, Yilinen_US
dc.contributor.authorLiu, Guangpengen_US
dc.contributor.authorJackson, John D.en_US
dc.contributor.authorYoo, James J.en_US
dc.contributor.authorAtala, Anthonyen_US
dc.contributor.authorvan den Beucken, Jeroen J.J.P.en_US
dc.contributor.authorJansen, John A.en_US
dc.contributor.authorKasper, F. Kurtisen_US
dc.contributor.authorHo, Tangen_US
dc.contributor.authorDemian, Nagien_US
dc.contributor.authorMiller, Michael Johnen_US
dc.contributor.authorWong, Mark E.en_US
dc.contributor.authorMikos, Antonios G.en_US
dc.date.accessioned2015-05-15T17:06:34Zen_US
dc.date.available2015-05-15T17:06:34Zen_US
dc.date.issued2015en_US
dc.description.abstractThe reconstruction of large craniofacial defects remains a significant clinical challenge. The complex geometry of facial bone and the lack of suitable donor tissue often hinders successful repair. One strategy to address both of these difficulties is the development of an in vivo bioreactor, where a tissue flap of suitable geometry can be orthotopically grown within the same patient requiring reconstruction. Our group has previously designed such an approach using tissue chambers filled with morcellized bone autograft as a scaffold to autologously generate tissue with a predefined geometry. However, this approach still required donor tissue for filling the tissue chamber. With the recent advances in biodegradable synthetic bone graft materials, it may be possible to minimize this donor tissue by replacing it with synthetic ceramic particles. In addition, these flaps have not previously been transferred to a mandibular defect. In this study, we demonstrate the feasibility of transferring an autologously generated tissue-engineered vascularized bone flap to a mandibular defect in an ovine model, using either morcellized autograft or synthetic bone graft as scaffold material.en_US
dc.identifier.citationTatara, Alexander M., Kretlow, James D., Spicer, Patrick P., et al.. "Autologously Generated Tissue-Engineered Bone Flaps for Reconstruction of Large Mandibular Defects in an Ovine Model." <i>Tissue Engineering Part A,</i> 21, no. 9-10 (2015) Mary Ann Liebert, Inc.: 1520-1528. http://dx.doi.org/10.1089/ten.tea.2014.0426.en_US
dc.identifier.doihttp://dx.doi.org/10.1089/ten.tea.2014.0426en_US
dc.identifier.urihttps://hdl.handle.net/1911/80224en_US
dc.language.isoengen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleAutologously Generated Tissue-Engineered Bone Flaps for Reconstruction of Large Mandibular Defects in an Ovine Modelen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ten.tea.2014.0426.pdf
Size:
592.06 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Bioengineering Publications