Interobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trialsﾠ

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dc.citation.firstpage474en_US
dc.citation.issueNumber4en_US
dc.citation.journalTitleOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyen_US
dc.citation.lastpage48200en_US
dc.citation.volumeNumber120en_US
dc.contributor.authorSpeight, Paul M.en_US
dc.contributor.authorAbram, Timothy J.en_US
dc.contributor.authorFloriano, Pierre N.en_US
dc.contributor.authorJames, Roberten_US
dc.contributor.authorVick, Julieen_US
dc.contributor.authorThornhill, Martin H.en_US
dc.contributor.authorMurdoch, Craigen_US
dc.contributor.authorFreeman, Christineen_US
dc.contributor.authorHegarty, Anne M.en_US
dc.contributor.authorD’Apice, Katyen_US
dc.contributor.authorKerr, A. Rossen_US
dc.contributor.authorPhelan, Joanen_US
dc.contributor.authorCorby, Patriciaen_US
dc.contributor.authorKhouly, Ismaelen_US
dc.contributor.authorVigneswaran, Nadarajahen_US
dc.contributor.authorBouquot, Jerryen_US
dc.contributor.authorDemian, Nagi M.en_US
dc.contributor.authorWeinstock, Y. Etanen_US
dc.contributor.authorRedding, Spencer W.en_US
dc.contributor.authorRowan, Stephanieen_US
dc.contributor.authorYeh, Chih-Koen_US
dc.contributor.authorMcGuff, H. Stanen_US
dc.contributor.authorMiller, Frank R.en_US
dc.contributor.authorMcDevitt, John T.en_US
dc.date.accessioned2016-10-21T17:01:00Zen_US
dc.date.available2016-10-21T17:01:00Zen_US
dc.date.issued2015en_US
dc.description.abstractObjective: Interobserver agreement in the context of oral epithelial dysplasia (OED) grading has been notoriously unreliable and can impose barriers for developing new molecular markers and diagnostic technologies. This paper aimed to report the details of a 3-stage histopathology review and adjudication process with the goal of achieving a consensus histopathologic diagnosis of each biopsy. Study Design: Two adjacent serial histologic sections of oral lesions from 846 patients were independently scored by 2 different pathologists from a pool of 4. In instances where the original 2 pathologists disagreed, a third, independent adjudicating pathologist conducted a review of both sections. If a majority agreement was not achieved, the third stage involved a face-to-face consensus review. Results: Individual pathologist pair κ values ranged from 0.251 to 0.706 (fair-good) before the 3-stage review process. During the initial review phase, the 2 pathologists agreed on a diagnosis for 69.9% of the cases. After the adjudication review by a third pathologist, an additional 22.8% of cases were given a consensus diagnosis (agreement of 2 out of 3 pathologists). After the face-to-face review, the remaining 7.3% of cases had a consensus diagnosis. Conclusions: The use of the defined protocol resulted in a substantial increase (30%) in diagnostic agreement and has the potential to improve the level of agreement for establishing gold standards for studies based on histopathologic diagnosis.en_US
dc.identifier.citationSpeight, Paul M., Abram, Timothy J., Floriano, Pierre N., et al.. "Interobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trialsﾠ." <i>Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,</i> 120, no. 4 (2015) Elsevier: 474-48200. http://dx.doi.org/10.1016/j.oooo.2015.05.023.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.oooo.2015.05.023en_US
dc.identifier.urihttps://hdl.handle.net/1911/91976en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.titleInterobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trialsﾠen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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