Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis

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dc.citation.firstpage328
dc.citation.issueNumber10
dc.citation.journalTitleActa Crystallographica Section F: Structural Biology Communications
dc.citation.lastpage333
dc.citation.volumeNumber77
dc.contributor.authorAlvarado, S. K.
dc.contributor.authorMiller, M. D.
dc.contributor.authorBhardwaj, M.
dc.contributor.authorThorson, J. S.
dc.contributor.authorVan Lanen, S. G.
dc.contributor.authorPhillips, G. N.
dc.date.accessioned2021-10-21T17:53:21Z
dc.date.available2021-10-21T17:53:21Z
dc.date.issued2021
dc.description.abstractThe 1.5 Å resolution crystal structure of DynU16, a protein identified in the dynemicin-biosynthetic gene cluster, is reported. The structure adopts a di-domain helix-grip fold with a uniquely positioned open cavity connecting the domains. The elongated dimensions of the cavity appear to be compatible with the geometry of a linear polyene, suggesting the involvement of DynU16 in the upstream steps of dynemicin biosynthesis.
dc.identifier.citationAlvarado, S. K., Miller, M. D., Bhardwaj, M., et al.. "Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis." <i>Acta Crystallographica Section F: Structural Biology Communications,</i> 77, no. 10 (2021) International Union of Crystallography: 328-333. https://doi.org/10.1107/S2053230X21008943.
dc.identifier.digitalS2053230X21008943
dc.identifier.doihttps://doi.org/10.1107/S2053230X21008943
dc.identifier.urihttps://hdl.handle.net/1911/111586
dc.language.isoeng
dc.publisherInternational Union of Crystallography
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleStructural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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