Accuracy and interrater reliability for the diagnosis of Barrett’s neoplasia among users of a novel, portable high-resolution microendoscope

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dc.citation.firstpage55en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitleDisease of the Esophagusen_US
dc.citation.lastpage62en_US
dc.citation.volumeNumber27en_US
dc.contributor.authorVila, P.M.en_US
dc.contributor.authorKingsley, M.J.en_US
dc.contributor.authorPolydorides, A.D.en_US
dc.contributor.authorProtano, M.-A.en_US
dc.contributor.authorPierce, M.C.en_US
dc.contributor.authorSauk, J.en_US
dc.contributor.authorKim, M.K.en_US
dc.contributor.authorPatel, K.en_US
dc.contributor.authorGodbold, J.H.en_US
dc.contributor.authorWaye, J.D.en_US
dc.contributor.authorRichards-Kortum, R.en_US
dc.contributor.authorAnandasabapathy, S.en_US
dc.date.accessioned2017-08-04T12:29:40Zen_US
dc.date.available2017-08-04T12:29:40Zen_US
dc.date.issued2014en_US
dc.description.abstractThe high-resolution microendoscope (HRME) is a novel imaging modality that may be useful in the surveillance of Barrett’s esophagus in low-resource or community-based settings. In order to assess accuracy and interrater reliability of microendoscopists in identifying Barrett’s-associated neoplasia using HRME images, we recruited 20 gastroenterologists with no microendoscopic experience and three expert microendoscopists in a large academic hospital in New York City to interpret HRME images. They prospectively reviewed 40 HRME images from 28 consecutive patients undergoing surveillance for metaplasia and low-grade dysplasia and/or evaluation for high-grade dysplasia or cancer. Images were reviewed in a blinded fashion, after a 4-minute training with 11 representative images. All imaged sites were biopsied and interpreted by an expert pathologist. Sensitivity of all endoscopists for identification of high-grade dysplasia or cancer was 0.90 (95% confidence interval [CI]: 0.88-0.92) and specificity was 0.82 (95% CI: 0.79-0.85). Positive and negative predictive values were 0.72 (95% CI: 0.68-0.77) and 0.94 (95% CI: 0.92-0.96), respectively. No significant differences in accuracy were observed between experts and novices (0.90 vs. 0.84). The kappa statistic for all raters was 0.56 (95% CI: 0.54-0.58), and the difference between groups was not significant (0.64 vs. 0.55). These data suggest that gastroenterologists can diagnose Barrett’s-related neoplasia on HRME images with high sensitivity and specificity, without the aid of prior microendoscopy experience.en_US
dc.identifier.citationVila, P.M., Kingsley, M.J., Polydorides, A.D., et al.. "Accuracy and interrater reliability for the diagnosis of Barrett’s neoplasia among users of a novel, portable high-resolution microendoscope." <i>Disease of the Esophagus,</i> 27, no. 1 (2014) Oxford University Press: 55-62. https://doi.org/10.1111/dote.12040.en_US
dc.identifier.digitalAccuracy_interrater_reliabilityen_US
dc.identifier.doihttps://doi.org/10.1111/dote.12040en_US
dc.identifier.urihttps://hdl.handle.net/1911/96571en_US
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.en_US
dc.subject.keywordcanceren_US
dc.subject.keyworddiagnostic imagingen_US
dc.subject.keywordesophagogastroduodenoscopyen_US
dc.subject.keywordoptical deviceen_US
dc.titleAccuracy and interrater reliability for the diagnosis of Barrett’s neoplasia among users of a novel, portable high-resolution microendoscopeen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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