Toward carbon nanotube-based imaging agents for the clinic

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dc.citation.firstpage229en_US
dc.citation.journalTitleBiomaterialsen_US
dc.citation.lastpage240en_US
dc.citation.volumeNumber101en_US
dc.contributor.authorHernández-Rivera, Mayraen_US
dc.contributor.authorZaibaq, Nicholas G.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.orgSmalley-Curl Instituteen_US
dc.date.accessioned2016-07-21T20:14:36Zen_US
dc.date.available2016-07-21T20:14:36Zen_US
dc.date.issued2016en_US
dc.description.abstractAmong the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivowill be essential to evaluate their biodistribution, potential toxicity, therapeutic activity, and any physiological changes that the material may induce in specific tissues. There are many different imaging modalities to visualize and track CNTs in vivo, yet only a few are full-body penetrating, a central characteristic that widens their clinical utility. In order to visualize CNTs, chemical modification is often required for the material to be used as a platform to carry imaging agents compatible with one or more of the clinical imaging techniques. Here, we focus on the most recent work involving the use of CNTs as imaging agents for the non-invasive, full-body penetrating clinical modalities of MRI, PET, SPECT, and X-ray CT. The synthesis and modification of the CNT materials are discussed, as well as relevant preclinical studies.en_US
dc.identifier.citationHernández-Rivera, Mayra, Zaibaq, Nicholas G. and Wilson, Lon J.. "Toward carbon nanotube-based imaging agents for the clinic." <i>Biomaterials,</i> 101, (2016) Elsevier: 229-240. http://dx.doi.org/10.1016/j.biomaterials.2016.05.045.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2016.05.045en_US
dc.identifier.urihttps://hdl.handle.net/1911/90940en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordcarbon nanotubesen_US
dc.subject.keywordclinical imagingen_US
dc.subject.keywordMRIen_US
dc.subject.keywordPETen_US
dc.subject.keywordSPECTen_US
dc.subject.keywordX-ray CTen_US
dc.titleToward carbon nanotube-based imaging agents for the clinicen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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