Investigating Multiple Candidate Genes and Nutrients in the Folate Metabolism Pathway to Detect Genetic and Nutritional Risk Factors for Lung Cancer

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dc.citation.firstpagee53475
dc.citation.issueNumber1
dc.citation.journalTitlePLoS One
dc.citation.volumeNumber8
dc.contributor.authorSwartz, Michael D.
dc.contributor.authorPeterson, Christine B.
dc.contributor.authorLupo, Philip J.
dc.contributor.authorWu, Xifeng
dc.contributor.authorForman, Michele R.
dc.contributor.authorSpitz, Margaret R.
dc.contributor.authorHernandez, Ladia M.
dc.contributor.authorVannucci, Marina
dc.contributor.authorShete, Sanjay
dc.date.accessioned2013-07-12T19:35:16Z
dc.date.available2013-07-12T19:35:16Z
dc.date.issued2013
dc.description.abstractPurpose: Folate metabolism, with its importance to DNA repair, provides a promising region for genetic investigation of lung cancer risk. This project investigates genes (MTHFR, MTR, MTRR, CBS, SHMT1, TYMS), folate metabolism related nutrients (B vitamins, methionine, choline, and betaine) and their gene-nutrient interactions. Methods: We analyzed 115 tag single nucleotide polymorphisms (SNPs) and 15 nutrients from 1239 and 1692 non-Hispanic white, histologically-confirmed lung cancer cases and controls, respectively, using stochastic search variable selection (a Bayesian model averaging approach). Analyses were stratified by current, former, and never smoking status. Results: Rs6893114 in MTRR (odds ratio [OR] = 2.10; 95% credible interval [CI]: 1.20–3.48) and alcohol (drinkers vs. non-drinkers, OR = 0.48; 95% CI: 0.26–0.84) were associated with lung cancer risk in current smokers. Rs13170530 in MTRR (OR = 1.70; 95% CI: 1.10–2.87) and two SNP*nutrient interactions [betaine*rs2658161 (OR = 0.42; 95% CI: 0.19–0.88) and betaine*rs16948305 (OR = 0.54; 95% CI: 0.30–0.91)] were associated with lung cancer risk in former smokers. SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11–0.58; rs10512948; OR = 0.61; 95% CI: 0.41–0.90; rs2924471; OR = 3.31; 95% CI: 1.66–6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43–0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11–2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27–0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15–0.95) were associated with lung cancer risk in never smokers. Conclusions: This study identified possible nutrient and genetic factors related to folate metabolism associated with lung cancer risk, which could potentially lead to nutritional interventions tailored by smoking status to reduce lung cancer risk.
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dc.identifier.citationSwartz, Michael D., Peterson, Christine B., Lupo, Philip J., et al.. "Investigating Multiple Candidate Genes and Nutrients in the Folate Metabolism Pathway to Detect Genetic and Nutritional Risk Factors for Lung Cancer." <i>PLoS One,</i> 8, no. 1 (2013) Public Library of Science: e53475. http://dx.doi.org/10.1371/journal.pone.0053475.
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0053475
dc.identifier.urihttps://hdl.handle.net/1911/71543
dc.language.isoeng
dc.publisherPublic Library of Science
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleInvestigating Multiple Candidate Genes and Nutrients in the Folate Metabolism Pathway to Detect Genetic and Nutritional Risk Factors for Lung Cancer
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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