Stable confinement of PET & MR agents within carbon nanotubes for bimodal imaging

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dc.citation.journalTitleNanomedicineen_US
dc.contributor.authorCisneros, Brandon T.en_US
dc.contributor.authorLaw, Justin J.en_US
dc.contributor.authorMatson, Michael L.en_US
dc.contributor.authorAzhdarinia, Alien_US
dc.contributor.authorSevick-Muraca, Eva M.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2014-07-30T16:23:07Zen_US
dc.date.available2014-07-30T16:23:07Zen_US
dc.date.issued2014en_US
dc.description.abstractSimultaneous PET/MR imaging has recently been introduced to the clinic and dual PET/MR imaging probes are rare and of growing interest. We have developed a strategy for producing multimodal probes based on a carbon nanotube platform without the use of chelating ligands. Materials and Methods: Gd3+ and 64Cu2+ ions were loaded into ultra-short single-walled carbon nanotubes (US-tubes) by sonication. Normal, tumor-free athymic nude mice were injected intravenously with the probe and imaged over 48 hrs. Results and Conclusions: The probe was stable for up to 24 hrs when challenged with PBS and mouse serum. PET imaging also confirmed the stability of the probe in vivo for up to 48 hrs. The probe was quickly cleared from circulation, with enhanced accumulation in the lungs. Stable encapsulation of contrast agents within US-tubes represents a new strategy for the design of advanced imaging probes with variable multimodal imaging capabilities.en_US
dc.identifier.citationCisneros, Brandon T., Law, Justin J., Matson, Michael L., et al.. "Stable confinement of PET & MR agents within carbon nanotubes for bimodal imaging." <i>Nanomedicine,</i> (2014) Future Medicine Ltd: http://dx.doi.org/10.2217/nnm.14.26.en_US
dc.identifier.doihttp://dx.doi.org/10.2217/nnm.14.26en_US
dc.identifier.urihttps://hdl.handle.net/1911/76288en_US
dc.language.isoengen_US
dc.publisherFuture Medicine Ltden_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Future Medicine Ltd.en_US
dc.subject.keywordcarbon nanotubesen_US
dc.subject.keywordcontrast agenten_US
dc.subject.keywordpositron emission tomographyen_US
dc.subject.keywordmagnetic resonance imagingen_US
dc.subject.keywordmultimodal imagingen_US
dc.titleStable confinement of PET & MR agents within carbon nanotubes for bimodal imagingen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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