Development of a multimodal mobile colposcope for real-time cervical cancer detection

Simple item page
dc.citation.firstpage5116en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleBiomedical Optics Expressen_US
dc.citation.lastpage5130en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorCoole, Jackson B.en_US
dc.contributor.authorBrenes, Daviden_US
dc.contributor.authorPossati-Resende, Júlio Césaren_US
dc.contributor.authorAntoniazzi, Márcioen_US
dc.contributor.authorFonseca, Bruno de Oliveiraen_US
dc.contributor.authorMaker, Yajuren_US
dc.contributor.authorKortum, Alexen_US
dc.contributor.authorVohra, Imran S.en_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorCarns, Jenniferen_US
dc.contributor.authorSouza, Karen Cristina Borbaen_US
dc.contributor.authorSantana, Iara Viana Vidigalen_US
dc.contributor.authorKreitchmann, Regisen_US
dc.contributor.authorSalcedo, Mila P.en_US
dc.contributor.authorSalcedo, Mila P.en_US
dc.contributor.authorRamanujam, Nirmalaen_US
dc.contributor.authorSchmeler, Kathleen M.en_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2022-10-28T17:43:03Zen_US
dc.date.available2022-10-28T17:43:03Zen_US
dc.date.issued2022en_US
dc.description.abstractCervical cancer remains a leading cause of cancer death among women in low-and middle-income countries. Globally, cervical cancer prevention programs are hampered by a lack of resources, infrastructure, and personnel. We describe a multimodal mobile colposcope (MMC) designed to diagnose precancerous cervical lesions at the point-of-care without the need for biopsy. The MMC integrates two complementary imaging systems: 1) a commercially available colposcope and 2) a high speed, high-resolution, fiber-optic microendoscope (HRME). Combining these two image modalities allows, for the first time, the ability to locate suspicious cervical lesions using widefield imaging and then to obtain co-registered high-resolution images across an entire lesion. The MMC overcomes limitations of high-resolution imaging alone; widefield imaging can be used to guide the placement of the high-resolution imaging probe at clinically suspicious regions and co-registered, mosaicked high-resolution images effectively increase the field of view of high-resolution imaging. Representative data collected from patients referred for colposcopy at Barretos Cancer Hospital in Brazil, including 22,800 high resolution images and 9,900 colposcope images, illustrate the ability of the MMC to identify abnormal cervical regions, image suspicious areas with subcellular resolution, and distinguish between high-grade and low-grade dysplasia.en_US
dc.identifier.citationCoole, Jackson B., Brenes, David, Possati-Resende, Júlio César, et al.. "Development of a multimodal mobile colposcope for real-time cervical cancer detection." <i>Biomedical Optics Express,</i> 13, no. 10 (2022) Optica Publishing Group: 5116-5130. https://doi.org/10.1364/BOE.463253.en_US
dc.identifier.digitalboe-13-10-5116en_US
dc.identifier.doihttps://doi.org/10.1364/BOE.463253en_US
dc.identifier.urihttps://hdl.handle.net/1911/113769en_US
dc.language.isoengen_US
dc.publisherOptica Publishing Groupen_US
dc.rightsPublished under the terms of the Optica Open Access Publishing Agreementen_US
dc.rights.urihttps://opg.optica.org/library/license_v2.cfm#VOR-OAen_US
dc.titleDevelopment of a multimodal mobile colposcope for real-time cervical cancer detectionen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
boe-13-10-5116.pdf
Size:
6.78 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications