Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model

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dc.citation.firstpage4574
dc.citation.issueNumber11
dc.citation.journalTitleActa Biomaterialia
dc.citation.lastpage4582
dc.citation.volumeNumber10
dc.contributor.authorKinard, Lucas A.
dc.contributor.authorDahlin, Rebecca L.
dc.contributor.authorLam, Johnny
dc.contributor.authorLu, Steven
dc.contributor.authorLee, Esther J.
dc.contributor.authorKasper, F. Kurtis
dc.contributor.authorMikos, Antonios G.
dc.date.accessioned2017-06-14T16:55:02Z
dc.date.available2017-06-14T16:55:02Z
dc.date.issued2014
dc.description.abstractThere exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has the potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1 or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Selected formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated in vivo compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation, exceeding 1:1 constructs and empty implants by 3- and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlates directly to the DBM dose.
dc.identifier.citationKinard, Lucas A., Dahlin, Rebecca L., Lam, Johnny, et al.. "Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model." <i>Acta Biomaterialia,</i> 10, no. 11 (2014) Elsevier: 4574-4582. https://doi.org/10.1016/j.actbio.2014.07.011.
dc.identifier.doihttps://doi.org/10.1016/j.actbio.2014.07.011
dc.identifier.urihttps://hdl.handle.net/1911/94836
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordBone augmentation
dc.subject.keywordDemineralized bone matrix
dc.subject.keywordOligo(poly(ethylene glycol) fumarate)
dc.subject.keywordSynthetic hydrogel
dc.titleSynthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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