Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model

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dc.citation.firstpage4574en_US
dc.citation.issueNumber11en_US
dc.citation.journalTitleActa Biomaterialiaen_US
dc.citation.lastpage4582en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorKinard, Lucas A.en_US
dc.contributor.authorDahlin, Rebecca L.en_US
dc.contributor.authorLam, Johnnyen_US
dc.contributor.authorLu, Stevenen_US
dc.contributor.authorLee, Esther J.en_US
dc.contributor.authorKasper, F. Kurtisen_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgChemical and Biomolecular Engineeringen_US
dc.date.accessioned2017-06-14T16:55:02Zen_US
dc.date.available2017-06-14T16:55:02Zen_US
dc.date.issued2014en_US
dc.description.abstractThere exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has the potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1 or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Selected formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated in vivo compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation, exceeding 1:1 constructs and empty implants by 3- and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlates directly to the DBM dose.en_US
dc.identifier.citationKinard, Lucas A., Dahlin, Rebecca L., Lam, Johnny, et al.. "Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model." <i>Acta Biomaterialia,</i> 10, no. 11 (2014) Elsevier: 4574-4582. https://doi.org/10.1016/j.actbio.2014.07.011.en_US
dc.identifier.doihttps://doi.org/10.1016/j.actbio.2014.07.011en_US
dc.identifier.urihttps://hdl.handle.net/1911/94836en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordBone augmentationen_US
dc.subject.keywordDemineralized bone matrixen_US
dc.subject.keywordOligo(poly(ethylene glycol) fumarate)en_US
dc.subject.keywordSynthetic hydrogelen_US
dc.titleSynthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat modelen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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