Coco is a dual activity modulator of TGFβ signaling

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dc.citation.firstpage2678en_US
dc.citation.journalTitleDevelopmenten_US
dc.citation.lastpage2685en_US
dc.citation.volumeNumber142en_US
dc.contributor.authorDeglincerti, Alessiaen_US
dc.contributor.authorHaremaki, Tomomien_US
dc.contributor.authorWarmflash, Aryehen_US
dc.contributor.authorSorre, Benoiten_US
dc.contributor.authorBrivanlou, Ali H.en_US
dc.date.accessioned2016-01-29T21:44:39Zen_US
dc.date.available2016-01-29T21:44:39Zen_US
dc.date.issued2015en_US
dc.description.abstractThe TGFβ signaling pathway is a crucial regulator of developmental processes and disease. The activity of TGFβ ligands is modulated by various families of soluble inhibitors that interfere with the interactions between ligands and receptors. In an unbiased, genome-wide RNAi screen to identify genes involved in ligand-dependent signaling, we unexpectedly identified the BMP/Activin/Nodal inhibitor Coco as an enhancer of TGFβ1 signaling. Coco synergizes with TGFβ1 in both cell culture and Xenopus explants. Molecularly, Coco binds to TGFβ1 and enhances TGFβ1 binding to its receptor Alk5. Thus, Coco acts as both an inhibitor and an enhancer of signaling depending on the ligand it binds. This finding raises the need for a global reconsideration of the molecular mechanisms regulating TGFβ signaling.en_US
dc.identifier.citationDeglincerti, Alessia, Haremaki, Tomomi, Warmflash, Aryeh, et al.. "Coco is a dual activity modulator of TGFβ signaling." <i>Development,</i> 142, (2015) The Company of Biologists: 2678-2685. http://dx.doi.org/10.1242/dev.122358.en_US
dc.identifier.doihttp://dx.doi.org/10.1242/dev.122358en_US
dc.identifier.urihttps://hdl.handle.net/1911/88283en_US
dc.language.isoengen_US
dc.publisherThe Company of Biologistsen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordCocoen_US
dc.subject.keywordTGFβ signaling modulatorsen_US
dc.subject.keyworddual-activity pathway modulatorsen_US
dc.titleCoco is a dual activity modulator of TGFβ signalingen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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