Coco is a dual activity modulator of TGFβ signaling

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dc.citation.firstpage2678
dc.citation.journalTitleDevelopment
dc.citation.lastpage2685
dc.citation.volumeNumber142
dc.contributor.authorDeglincerti, Alessia
dc.contributor.authorHaremaki, Tomomi
dc.contributor.authorWarmflash, Aryeh
dc.contributor.authorSorre, Benoit
dc.contributor.authorBrivanlou, Ali H.
dc.date.accessioned2016-01-29T21:44:39Z
dc.date.available2016-01-29T21:44:39Z
dc.date.issued2015
dc.description.abstractThe TGFβ signaling pathway is a crucial regulator of developmental processes and disease. The activity of TGFβ ligands is modulated by various families of soluble inhibitors that interfere with the interactions between ligands and receptors. In an unbiased, genome-wide RNAi screen to identify genes involved in ligand-dependent signaling, we unexpectedly identified the BMP/Activin/Nodal inhibitor Coco as an enhancer of TGFβ1 signaling. Coco synergizes with TGFβ1 in both cell culture and Xenopus explants. Molecularly, Coco binds to TGFβ1 and enhances TGFβ1 binding to its receptor Alk5. Thus, Coco acts as both an inhibitor and an enhancer of signaling depending on the ligand it binds. This finding raises the need for a global reconsideration of the molecular mechanisms regulating TGFβ signaling.
dc.identifier.citationDeglincerti, Alessia, Haremaki, Tomomi, Warmflash, Aryeh, et al.. "Coco is a dual activity modulator of TGFβ signaling." <i>Development,</i> 142, (2015) The Company of Biologists: 2678-2685. http://dx.doi.org/10.1242/dev.122358.
dc.identifier.doihttp://dx.doi.org/10.1242/dev.122358
dc.identifier.urihttps://hdl.handle.net/1911/88283
dc.language.isoeng
dc.publisherThe Company of Biologists
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.subject.keywordCoco
dc.subject.keywordTGFβ signaling modulators
dc.subject.keyworddual-activity pathway modulators
dc.titleCoco is a dual activity modulator of TGFβ signaling
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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