Cofactor engineering for advancing chemical biotechnology

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dc.citation.firstpage994
dc.citation.journalTitleCurrent Opinion in Biotechnology
dc.citation.lastpage999
dc.citation.volumeNumber24
dc.contributor.authorWang, Yipeng
dc.contributor.authorSan, Ka-Yiu
dc.contributor.authorBennett, George N.
dc.date.accessioned2014-02-14T21:19:55Z
dc.date.available2014-02-14T21:19:55Z
dc.date.issued2013
dc.description.abstractCofactors provide redox carriers for biosynthetic reactions, catabolic reactions and act as important agents in transfer of energy for the cell. Recent advances in manipulating cofactors include culture conditions or additive alterations, genetic modification of host pathways for increased availability of desired cofactor, changes in enzyme cofactor specificity, and introduction of novel redox partners to form effective circuits for biochemical processes and biocatalysts. Genetic strategies to employ ferredoxin, NADH and NADPH most effectively in natural or novel pathways have improved yield and efficiency of large-scale processes for fuels and chemicals and have been demonstrated with a variety of microbial organisms.
dc.identifier.citationWang, Yipeng, San, Ka-Yiu and Bennett, George N.. "Cofactor engineering for advancing chemical biotechnology." <i>Current Opinion in Biotechnology,</i> 24, (2013) Elsevier: 994-999. http://dx.doi.org/10.1016/j.copbio.2013.03.022.
dc.identifier.doihttp://dx.doi.org/10.1016/j.copbio.2013.03.022
dc.identifier.urihttps://hdl.handle.net/1911/75475
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.titleCofactor engineering for advancing chemical biotechnology
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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