Carbon nanotube micropillars trigger guided growth of complex human neural stem cells networks

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dc.citation.firstpage2894en_US
dc.citation.journalTitleNano Researchen_US
dc.citation.lastpage2899en_US
dc.citation.volumeNumber12en_US
dc.contributor.authorLorite, Gabriela S.en_US
dc.contributor.authorYlä-Outinen, Lauraen_US
dc.contributor.authorJanssen, Laurianeen_US
dc.contributor.authorPitkänen, Ollien_US
dc.contributor.authorJoki, Tiinaen_US
dc.contributor.authorKoivisto, Janne T.en_US
dc.contributor.authorKellomäki, Minnaen_US
dc.contributor.authorVajtai, Roberten_US
dc.contributor.authorNarkilahti, Susannaen_US
dc.contributor.authorKordas, Krisztianen_US
dc.date.accessioned2020-02-14T16:39:39Zen_US
dc.date.available2020-02-14T16:39:39Zen_US
dc.date.issued2019en_US
dc.description.abstractNew strategies for spatially controlled growth of human neurons may provide viable solutions to treat and recover peripheral or spinal cord injuries. While topography cues are known to promote attachment and direct proliferation of many cell types, guided outgrowth of human neurites has been found difficult to achieve so far. Here, three-dimensional (3D) micropatterned carbon nanotube (CNT) templates are used to effectively direct human neurite stem cell growth. By exploiting the mechanical flexibility, electrically conductivity and texture of the 3D CNT micropillars, a perfect environment is created to achieve specific guidance of human neurites, which may lead to enhanced therapeutic effects within the injured spinal cord or peripheral nerves. It is found that the 3D CNT micropillars grant excellent anchoring for adjacent neurites to form seamless neuronal networks that can be grown to any arbitrary shape and size. Apart from clear practical relevance in regenerative medicine, these results using the CNT based templates on Si chips also can pave the road for new types of microelectrode arrays to study cell network electrophysiology.en_US
dc.identifier.citationLorite, Gabriela S., Ylä-Outinen, Laura, Janssen, Lauriane, et al.. "Carbon nanotube micropillars trigger guided growth of complex human neural stem cells networks." <i>Nano Research,</i> 12, (2019) Springer: 2894-2899. https://doi.org/10.1007/s12274-019-2533-2.en_US
dc.identifier.digitalLorite2019en_US
dc.identifier.doihttps://doi.org/10.1007/s12274-019-2533-2en_US
dc.identifier.urihttps://hdl.handle.net/1911/108037en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleCarbon nanotube micropillars trigger guided growth of complex human neural stem cells networksen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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