Self-assembling multidomain peptides tailor biological responses through biphasic release

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dc.citation.firstpage71en_US
dc.citation.journalTitleBiomaterialsen_US
dc.citation.lastpage78en_US
dc.citation.volumeNumber52en_US
dc.contributor.authorKumar, Vivek A.en_US
dc.contributor.authorTaylor, Nichole L.en_US
dc.contributor.authorShi, Siyuen_US
dc.contributor.authorWickremasinghe, Navindee C.en_US
dc.contributor.authorD’Souza, Rena N.en_US
dc.contributor.authorHartgerink, Jeffrey D.en_US
dc.date.accessioned2017-06-14T18:46:24Zen_US
dc.date.available2017-06-14T18:46:24Zen_US
dc.date.issued2015en_US
dc.description.abstractDelivery of small molecules and drugs to tissues is a mainstay of several tissue engineering strategies. Next generation treatments focused on localized drug delivery offer a more effective means in dealing with refractory healing when compared to systemic approaches. Here we describe a novel multidomain peptide hydrogel that capitalizes on synthetic peptide chemistry, supramolecular self-assembly and cytokine delivery to tailor biological responses. This material is biomimetic, shows shear stress recovery and offers a nanofibrous matrix that sequesters cytokines. The biphasic pattern of cytokine release results in the spatio-temporal activation of THP-1 monocytes and macrophages. Furthermore, macrophage–material interactions are promoted without generation of a proinflammatory environment. Subcutaneous implantation of injectable scaffolds showed a marked increase in macrophage infiltration and polarization dictated by cytokine loading as early as 3 days, with complete scaffold resorption by day 14. Macrophage interaction and response to the peptide composite facilitated the (i) recruitment of monocytes/macrophages, (ii) sustained residence of immune cells until degradation, and (iii) promotion of a pro-resolution M2 environment. Our results suggest the potential use of this injectable cytokine loaded hydrogel scaffold in a variety of tissue engineering applications.en_US
dc.identifier.citationKumar, Vivek A., Taylor, Nichole L., Shi, Siyu, et al.. "Self-assembling multidomain peptides tailor biological responses through biphasic release." <i>Biomaterials,</i> 52, (2015) Elsevier: 71-78. https://doi.org/10.1016/j.biomaterials.2015.01.079.en_US
dc.identifier.doihttps://doi.org/10.1016/j.biomaterials.2015.01.079en_US
dc.identifier.urihttps://hdl.handle.net/1911/94847en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordInflammationen_US
dc.subject.keywordMacrophage polarizationen_US
dc.subject.keywordMulti-domain peptideen_US
dc.subject.keywordSelf-assemblyen_US
dc.titleSelf-assembling multidomain peptides tailor biological responses through biphasic releaseen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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