Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects

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dc.citation.firstpage139
dc.citation.issueNumberSuppl 1
dc.citation.journalTitleBiomarker Insights
dc.citation.lastpage146
dc.citation.volumeNumber10
dc.contributor.authorGao, Yang
dc.contributor.authorJacot, Jeffrey G.
dc.date.accessioned2015-11-09T18:52:17Z
dc.date.available2015-11-09T18:52:17Z
dc.date.issued2015
dc.description.abstractSynthetic patches and fixed grafts currently used in the repair of congenital heart defects are nonliving, noncontractile, and not electrically responsive, leading to increased risk of complication, reoperation, and sudden cardiac death. Studies suggest that tissue-engineered patches made from living, functional cells could grow with the patient, facilitate healing, and help recover cardiac function. In this paper, we review the research into possible sources of cardiomyocytes and other cardiac cells, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, adipose-derived stem cells, umbilical cord blood cells, amniotic fluid-derived stem cells, and cardiac progenitor cells. Each cell source has advantages, but also has technical hurdles to overcome, including heterogeneity, functional maturity, immunogenicity, and pathogenicity. Additionally, biomaterials used as patch materials will need to attract and support desired cells and induce minimal immune responses.
dc.identifier.citationGao, Yang and Jacot, Jeffrey G.. "Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects." <i>Biomarker Insights,</i> 10, no. Suppl 1 (2015) Libertas Academica Ltd: 139-146. http://dx.doi.org/10.4137/BMI.S20058.
dc.identifier.doihttp://dx.doi.org/10.4137/BMI.S20058
dc.identifier.urihttps://hdl.handle.net/1911/82037
dc.language.isoeng
dc.publisherLibertas Academica Ltd
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/us/
dc.subject.keywordstem cells
dc.subject.keywordprogenitor cells
dc.subject.keywordcongenital heart defects
dc.subject.keywordcardiac tissue engineering
dc.titleStem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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