Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects

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dc.citation.firstpage139en_US
dc.citation.issueNumberSuppl 1en_US
dc.citation.journalTitleBiomarker Insightsen_US
dc.citation.lastpage146en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorGao, Yangen_US
dc.contributor.authorJacot, Jeffrey G.en_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2015-11-09T18:52:17Zen_US
dc.date.available2015-11-09T18:52:17Zen_US
dc.date.issued2015en_US
dc.description.abstractSynthetic patches and fixed grafts currently used in the repair of congenital heart defects are nonliving, noncontractile, and not electrically responsive, leading to increased risk of complication, reoperation, and sudden cardiac death. Studies suggest that tissue-engineered patches made from living, functional cells could grow with the patient, facilitate healing, and help recover cardiac function. In this paper, we review the research into possible sources of cardiomyocytes and other cardiac cells, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, adipose-derived stem cells, umbilical cord blood cells, amniotic fluid-derived stem cells, and cardiac progenitor cells. Each cell source has advantages, but also has technical hurdles to overcome, including heterogeneity, functional maturity, immunogenicity, and pathogenicity. Additionally, biomaterials used as patch materials will need to attract and support desired cells and induce minimal immune responses.en_US
dc.identifier.citationGao, Yang and Jacot, Jeffrey G.. "Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects." <i>Biomarker Insights,</i> 10, no. Suppl 1 (2015) Libertas Academica Ltd: 139-146. http://dx.doi.org/10.4137/BMI.S20058.en_US
dc.identifier.doihttp://dx.doi.org/10.4137/BMI.S20058en_US
dc.identifier.urihttps://hdl.handle.net/1911/82037en_US
dc.language.isoengen_US
dc.publisherLibertas Academica Ltden_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/us/en_US
dc.subject.keywordstem cellsen_US
dc.subject.keywordprogenitor cellsen_US
dc.subject.keywordcongenital heart defectsen_US
dc.subject.keywordcardiac tissue engineeringen_US
dc.titleStem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defectsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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