Porous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcare

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dc.citation.firstpage15467en_US
dc.citation.journalTitleSensorsen_US
dc.citation.lastpage15499en_US
dc.citation.volumeNumber12en_US
dc.contributor.authorChou, Jieen_US
dc.contributor.authorWong, Jorgeen_US
dc.contributor.authorChristodoulides, Nicolaosen_US
dc.contributor.authorFloriano, Pierre N.en_US
dc.contributor.authorSanchez, Ximenaen_US
dc.contributor.authorMcDevitt, Johnen_US
dc.date.accessioned2013-08-22T23:04:12Zen_US
dc.date.available2013-08-22T23:04:12Zen_US
dc.date.issued2012en_US
dc.description.abstractAdvances in lab-on-a-chip systems have strong potential for multiplexed detection of a wide range of analytes with reduced sample and reagent volume; lower costs and shorter analysis times. The completion of high-fidelity multiplexed and multiclass assays remains a challenge for the medical microdevice field; as it struggles to achieve and expand upon at the point-of-care the quality of results that are achieved now routinely in remote laboratory settings. This review article serves to explore for the first time the key intersection of multiplexed bead-based detection systems with integrated microfluidic structures alongside porous capture elements together with biomarker validation studies. These strategically important elements are evaluated here in the context of platform generation as suitable for near-patient testing. Essential issues related to the scalability of these modular sensor ensembles are explored as are attempts to move such multiplexed and multiclass platforms into large-scale clinical trials. Recent efforts in these bead sensors have shown advantages over planar microarrays in terms of their capacity to generate multiplexed test results with shorter analysis times. Through high surface-to-volume ratios and encoding capabilities; porous bead-based ensembles; when combined with microfluidic elements; allow for high-throughput testing for enzymatic assays; general chemistries; protein; antibody and oligonucleotide applications.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationChou, Jie, Wong, Jorge, Christodoulides, Nicolaos, et al.. "Porous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcare." <i>Sensors,</i> 12, (2012) MPDI: 15467-15499. http://dx.doi.org/10.3390/s121115467.en_US
dc.identifier.doihttp://dx.doi.org/10.3390/s121115467en_US
dc.identifier.urihttps://hdl.handle.net/1911/71769en_US
dc.language.isoengen_US
dc.publisherMPDIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).en_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/en_US
dc.subject.keywordpoint-of-careen_US
dc.subject.keywordbeadsen_US
dc.subject.keywordporousen_US
dc.subject.keywordimmunoassaysen_US
dc.subject.keywordmicrofluidicsen_US
dc.subject.keywordclinical chemistryen_US
dc.subject.keywordvalidationen_US
dc.titlePorous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcareen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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