Tissue engineering perfusable cancer models

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dc.citation.firstpage112
dc.citation.journalTitleCurrent Opinion in Chemical Engineering
dc.citation.lastpage117
dc.citation.volumeNumber3
dc.contributor.authorFong, E.L.
dc.contributor.authorSantoro, M.
dc.contributor.authorFarach-Carson, Mary C.
dc.contributor.authorKasper, F.K.
dc.contributor.authorMikos, A.G.
dc.date.accessioned2015-03-16T16:56:10Z
dc.date.available2015-03-16T16:56:10Z
dc.date.issued2014
dc.description.abstractThe effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be modeled with high spatiotemporal control, microfluidic tumor models have demonstrated applicability as platforms to study cell-cell interactions, effect of interstitial flow on tumor migration and the role of vascular barrier function. To account for the multi-scale nature of cancer growth and invasion, macroscale models are also necessary. The consideration of fluid dynamics within tumor models at both the micro- and macroscopic levels may greatly improve our ability to more fully mimic the tumor microenvironment.
dc.identifier.citationFong, E.L., Santoro, M., Farach-Carson, Mary C., et al.. "Tissue engineering perfusable cancer models." <i>Current Opinion in Chemical Engineering,</i> 3, (2014) Elsevier: 112-117. http://dx.doi.org/10.1016/j.coche.2013.12.008.
dc.identifier.doihttp://dx.doi.org/10.1016/j.coche.2013.12.008
dc.identifier.urihttps://hdl.handle.net/1911/79351
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordtissue engineering
dc.subject.keywordcancer
dc.subject.keywordperfusion
dc.subject.keywordtumor models
dc.subject.keywordfluid flow
dc.titleTissue engineering perfusable cancer models
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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