Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates

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dc.citation.firstpage33163
dc.citation.issueNumber40
dc.citation.journalTitleThe Journal of Biological Chemistry
dc.citation.lastpage33178
dc.citation.volumeNumber287
dc.contributor.authorSalter, Mallory D.
dc.contributor.authorBlouin, George C.
dc.contributor.authorSoman, Jayashree
dc.contributor.authorSingleton, Eileen Willey
dc.contributor.authorDewilde, Sylvia
dc.contributor.authorMoens, Luc
dc.contributor.authorPesce, Alessandra
dc.contributor.authorNardini, Marco
dc.contributor.authorBolognesi, Martino
dc.contributor.authorOlson, John S.
dc.date.accessioned2013-03-21T14:43:42Z
dc.date.available2014-03-22T05:10:04Z
dc.date.issued2012
dc.description.abstractBackground: O2 pathways in animal hemoglobins and myoglobins are controversial. Results: Ligands enter and exit sperm whale Mb and Cerebratulus lacteus Hb by completely different pathways. Conclusion: Rational mutagenesis mapping can identify ligand migration pathways and provides experimental benchmarks for testing molecular dynamics simulations. Significance: Globins can use either a polar gate or an apolar tunnel for ligand entry.
dc.embargo.terms1 year
dc.identifier.citationSalter, Mallory D., Blouin, George C., Soman, Jayashree, et al.. "Determination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates." <i>The Journal of Biological Chemistry,</i> 287, no. 40 (2012) The American Society for Biochemistry and Molecular Biology, Inc.: 33163-33178. http://dx.doi.org/10.1074/jbc.M112.392258.
dc.identifier.doihttp://dx.doi.org/10.1074/jbc.M112.392258
dc.identifier.urihttps://hdl.handle.net/1911/70807
dc.language.isoeng
dc.publisherThe American Society for Biochemistry and Molecular Biology, Inc.
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleDetermination of Ligand Pathways in Globins: Apolar Tunnels Versus Polar Gates
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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