Modular video endoscopy for in vivo cross-polarized and vital-dye fluorescence imaging of Barrett's-associated neoplasia

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dc.citation.firstpage26007
dc.citation.issueNumber2
dc.citation.journalTitleJournal of Biomedical Optics
dc.citation.volumeNumber18
dc.contributor.authorThekkek, Nadhi
dc.contributor.authorPierce, Mark C.
dc.contributor.authorLee, Michelle H.
dc.contributor.authorPolydorides, Alexandros D.
dc.contributor.authorFlores, Raja M.
dc.contributor.authorAnandasabapathy, Sharmila
dc.contributor.authorRichards-Kortum, Rebecca R.
dc.date.accessioned2013-03-19T17:45:33Z
dc.date.available2013-03-19T17:45:33Z
dc.date.issued2013-02
dc.description.abstractA modular video endoscope is developed and tested to allow imaging in different modalities. This system incorporates white light imaging (WLI), cross-polarized imaging (CPI), and vital-dye fluorescence imaging (VFI), using interchangeable filter modules. CPI and VFI are novel endoscopic modalities that probe mucosal features associated with Barrett's neoplasia. CPI enhances vasculature, while VFI enhances glandular architecture. In this pilot study, we demonstrate the integration of these modalities by imaging areas of Barrett's metaplasia and neoplasia in an esophagectomy specimen. We verify that those key image features are also observed during an in vivo surveillance procedure. CPI images demonstrate improved visualization of branching blood vessels associated with neoplasia. VFI images show glandular architecture with increased glandular effacement associated with neoplasia. Results suggests that important pathologic features seen in CPI and VFI are not visible during standard endoscopic white light imaging, and thus the modalities may be useful in future in vivo studies for discriminating neoplasia from Barrett's metaplasia. We further demonstrate that the integrated WLI/CPI/VFI endoscope is compatible with complementary high-resolution endomicroscopy techniques such as the high-resolution microendoscope, potentially enabling two-step (“red-flag” widefield plus confirmatory high-resolution imaging) protocols to be enhanced.
dc.embargo.termsnone
dc.identifier.citationThekkek, Nadhi, Pierce, Mark C., Lee, Michelle H., et al.. "Modular video endoscopy for in vivo cross-polarized and vital-dye fluorescence imaging of Barrett's-associated neoplasia." <i>Journal of Biomedical Optics,</i> 18, no. 2 (2013) SPIE: 26007. http://dx.doi.org/10.1117/1.JBO.18.2.026007.
dc.identifier.doihttp://dx.doi.org/10.1117/1.JBO.18.2.026007
dc.identifier.urihttps://hdl.handle.net/1911/70723
dc.language.isoeng
dc.publisherSPIE
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.subject.keywordendoscopy
dc.subject.keywordimaging
dc.subject.keywordfluorescence
dc.subject.keywordcross-polarization
dc.subject.keywordcontrast agent
dc.subject.keywordvital-dye
dc.subject.keywordBarrett's esophagus
dc.subject.keywordesophageal adenocarcinoma
dc.titleModular video endoscopy for in vivo cross-polarized and vital-dye fluorescence imaging of Barrett's-associated neoplasia
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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