Bismuth@US-tubes as a potential contrast agent for X-ray imaging applications

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dc.citation.firstpage4792
dc.citation.issueNumber37
dc.citation.journalTitleJournal of Materials Chemistry B
dc.citation.lastpage4800
dc.citation.volumeNumber1
dc.contributor.authorRivera, Eladio J.
dc.contributor.authorTran, Lesa A.
dc.contributor.authorHernández-Rivera, Mayra
dc.contributor.authorYoon, Diana
dc.contributor.authorMikos, Antonios G.
dc.contributor.authorRusakova, Irene A.
dc.contributor.authorCheong, Benjamin Y.
dc.contributor.authorCabreira-Hansen, Maria da Graça
dc.contributor.authorWillerson, James T.
dc.contributor.authorPerin, Emerson C.
dc.contributor.authorWilson, Lon J.
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science & Technology
dc.date.accessioned2015-07-10T15:47:01Z
dc.date.available2015-07-10T15:47:01Z
dc.date.issued2013
dc.description.abstractThe encapsulation of bismuth as BiOCl/Bi2O3 within ultra-short (ca. 50 nm) single-walled carbon nanocapsules (US-tubes) has been achieved. The Bi@US-tubes have been characterized by high-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Bi@US-tubes have been used for intracellular labeling of pig bone marrow-derived mesenchymal stem cells (MSCs) to show high X-ray contrast in computed tomography (CT) cellular imaging for the first time. The relatively high contrast is achieved with low bismuth loading (2.66% by weight) within the US-tubes and without compromising cell viability. X-ray CT imaging of Bi@US-tubes-labeled MSCs showed a nearly two-fold increase in contrast enhancement when compared to unlabeled MSCs in a 100 kV CT clinical scanner. The CT signal enhancement from the Bi@US-tubes is 500 times greater than polymer-coated Bi2S3 nanoparticles and several-fold that of any clinical iodinated contrast agent (CA) at the same concentration. Our findings suggest that the Bi@US-tubes can be used as a potential new class of X-ray CT agent for stem cell labeling and possibly in vivo tracking.
dc.identifier.citationRivera, Eladio J., Tran, Lesa A., Hernández-Rivera, Mayra, et al.. "Bismuth@US-tubes as a potential contrast agent for X-ray imaging applications." <i>Journal of Materials Chemistry B,</i> 1, no. 37 (2013) Royal Society of Chemistry: 4792-4800. http://dx.doi.org/10.1039/C3TB20742K.
dc.identifier.doihttp://dx.doi.org/10.1039/C3TB20742K
dc.identifier.urihttps://hdl.handle.net/1911/80883
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.
dc.titleBismuth@US-tubes as a potential contrast agent for X-ray imaging applications
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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