A New Theoretical Approach to Analyze Complex Processes in Cytoskeleton Proteins

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dc.citation.firstpage2966
dc.citation.issueNumber11
dc.citation.journalTitleThe Journal of Physical Chemistry B
dc.citation.lastpage2972
dc.citation.volumeNumber118
dc.contributor.authorLi, Xin
dc.contributor.authorKolomeisky, Anatoly B.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2014-07-31T21:17:59Z
dc.date.available2014-07-31T21:17:59Z
dc.date.issued2014
dc.description.abstractCytoskeleton proteins are filament structures that support a large number of important biological processes. These dynamic biopolymers exist in non-equilibrium conditions stimulated by hydrolysis chemical reactions in their monomers. Current theoretical methods provide a comprehensive picture of biochemical and biophysical processes in cytoskeleton proteins. However, the description is only qualitative at biologically relevant conditions because utilized theoretical mean-field models neglect correlations. We develop a new theoretical method to describe dynamic processes in cytoskeleton proteins that takes into account spatial correlations in the chemical composition of these biopolymers. Our approach is based on analysis of probabilities of different clusters of subunits. It allows us to obtain exact analytical expressions for a variety of dynamic properties of cytoskeleton filaments. By comparing theoretical predictions with Monte Carlo computer simulations it is shown that our method provides a fully quantitative description of complex dynamic phenomena in cytoskeleton proteins at all conditions.
dc.identifier.citationLi, Xin and Kolomeisky, Anatoly B.. "A New Theoretical Approach to Analyze Complex Processes in Cytoskeleton Proteins." <i>The Journal of Physical Chemistry B,</i> 118, no. 11 (2014) American Chemical Society: 2966-2972. http://dx.doi.org/10.1021/jp500268q.
dc.identifier.doihttp://dx.doi.org/10.1021/jp500268q
dc.identifier.urihttps://hdl.handle.net/1911/76314
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.titleA New Theoretical Approach to Analyze Complex Processes in Cytoskeleton Proteins
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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