A de novo matrix for macroscopic living materials from bacteria

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dc.citation.articleNumber5544en_US
dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber13en_US
dc.contributor.authorMolinari, Saraen_US
dc.contributor.authorTesoriero, Robert F.en_US
dc.contributor.authorLi, Dongen_US
dc.contributor.authorSridhar, Swethaen_US
dc.contributor.authorCai, Rongen_US
dc.contributor.authorSoman, Jayashreeen_US
dc.contributor.authorRyan, Kathleen R.en_US
dc.contributor.authorAshby, Paul D.en_US
dc.contributor.authorAjo-Franklin, Caroline M.en_US
dc.date.accessioned2022-10-28T17:43:10Zen_US
dc.date.available2022-10-28T17:43:10Zen_US
dc.date.issued2022en_US
dc.description.abstractEngineered living materials (ELMs) embed living cells in a biopolymer matrix to create materials with tailored functions. While bottom-up assembly of macroscopic ELMs with a de novo matrix would offer the greatest control over material properties, we lack the ability to genetically encode a protein matrix that leads to collective self-organization. Here we report growth of ELMs from Caulobacter crescentus cells that display and secrete a self-interacting protein. This protein formed a de novo matrix and assembled cells into centimeter-scale ELMs. Discovery of design and assembly principles allowed us to tune the composition, mechanical properties, and catalytic function of these ELMs. This work provides genetic tools, design and assembly rules, and a platform for growing ELMs with control over both matrix and cellular structure and function.en_US
dc.identifier.citationMolinari, Sara, Tesoriero, Robert F., Li, Dong, et al.. "A de novo matrix for macroscopic living materials from bacteria." <i>Nature Communications,</i> 13, (2022) Springer Nature: https://doi.org/10.1038/s41467-022-33191-2.en_US
dc.identifier.digitals41467-022-33191-2en_US
dc.identifier.doihttps://doi.org/10.1038/s41467-022-33191-2en_US
dc.identifier.urihttps://hdl.handle.net/1911/113776en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleA de novo matrix for macroscopic living materials from bacteriaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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