Deep convolutional models improve predictions of macaque V1 responses to natural images

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dc.citation.articleNumbere1006897
dc.citation.issueNumber4
dc.citation.journalTitlePLoS Computational Biology
dc.citation.volumeNumber15
dc.contributor.authorCadena, Santiago A.
dc.contributor.authorDenfield, George H.
dc.contributor.authorWalker, Edgar Y.
dc.contributor.authorGatys, Leon A.
dc.contributor.authorTolias, Andreas S.
dc.contributor.authorBethge, Matthias
dc.contributor.authorEcker, Alexander S.
dc.date.accessioned2021-12-17T20:08:21Z
dc.date.available2021-12-17T20:08:21Z
dc.date.issued2019
dc.description.abstractDespite great efforts over several decades, our best models of primary visual cortex (V1) still predict spiking activity quite poorly when probed with natural stimuli, highlighting our limited understanding of the nonlinear computations in V1. Recently, two approaches based on deep learning have emerged for modeling these nonlinear computations: transfer learning from artificial neural networks trained on object recognition and data-driven convolutional neural network models trained end-to-end on large populations of neurons. Here, we test the ability of both approaches to predict spiking activity in response to natural images in V1 of awake monkeys. We found that the transfer learning approach performed similarly well to the data-driven approach and both outperformed classical linear-nonlinear and wavelet-based feature representations that build on existing theories of V1. Notably, transfer learning using a pre-trained feature space required substantially less experimental time to achieve the same performance. In conclusion, multi-layer convolutional neural networks (CNNs) set the new state of the art for predicting neural responses to natural images in primate V1 and deep features learned for object recognition are better explanations for V1 computation than all previous filter bank theories. This finding strengthens the necessity of V1 models that are multiple nonlinearities away from the image domain and it supports the idea of explaining early visual cortex based on high-level functional goals.
dc.identifier.citationCadena, Santiago A., Denfield, George H., Walker, Edgar Y., et al.. "Deep convolutional models improve predictions of macaque V1 responses to natural images." <i>PLoS Computational Biology,</i> 15, no. 4 (2019) Public Library of Science: https://doi.org/10.1371/journal.pcbi.1006897.
dc.identifier.digitaldocument-1
dc.identifier.doihttps://doi.org/10.1371/journal.pcbi.1006897
dc.identifier.urihttps://hdl.handle.net/1911/111877
dc.language.isoeng
dc.publisherPublic Library of Science
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDeep convolutional models improve predictions of macaque V1 responses to natural images
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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