Role of miR-2392 in driving SARS-CoV-2 infection

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dc.citation.articleNumber109839
dc.citation.issueNumber3
dc.citation.journalTitleCell Reports
dc.citation.volumeNumber37
dc.contributor.authorMcDonald, J. Tyson
dc.contributor.authorEnguita, Francisco J.
dc.contributor.authorTaylor, Deanne
dc.contributor.authorGriffin, Robert J.
dc.contributor.authorPriebe, Waldemar
dc.contributor.authorEmmett, Mark R.
dc.contributor.authorSajadi, Mohammad M.
dc.contributor.authorHarris, Anthony D.
dc.contributor.authorClement, Jean
dc.contributor.authorDybas, Joseph M.
dc.contributor.authorAykin-Burns, Nukhet
dc.contributor.authorGuarnieri, Joseph W.
dc.contributor.authorSingh, Larry N.
dc.contributor.authorGrabham, Peter
dc.contributor.authorBaylin, Stephen B.
dc.contributor.authorYousey, Aliza
dc.contributor.authorPearson, Andrea N.
dc.contributor.authorCorry, Peter M.
dc.contributor.authorSaravia-Butler, Amanda
dc.contributor.authorAunins, Thomas R.
dc.contributor.authorSharma, Sadhana
dc.contributor.authorNagpal, Prashant
dc.contributor.authorMeydan, Cem
dc.contributor.authorFoox, Jonathan
dc.contributor.authorMozsary, Christopher
dc.contributor.authorCerqueira, Bianca
dc.contributor.authorZaksas, Viktorija
dc.contributor.authorSingh, Urminder
dc.contributor.authorWurtele, Eve Syrkin
dc.contributor.authorCostes, Sylvain V.
dc.contributor.authorDavanzo, Gustavo Gastão
dc.contributor.authorGaleano, Diego
dc.contributor.authorPaccanaro, Alberto
dc.contributor.authorMeinig, Suzanne L.
dc.contributor.authorHagan, Robert S.
dc.contributor.authorBowman, Natalie M.
dc.contributor.authorWallet, Shannon M.
dc.contributor.authorMaile, Robert
dc.contributor.authorWolfgang, Matthew C.
dc.contributor.authorHagan, Robert S.
dc.contributor.authorMock, Jason R.
dc.contributor.authorBowman, Natalie M.
dc.contributor.authorTorres-Castillo, Jose L.
dc.contributor.authorLove, Miriya K.
dc.contributor.authorMeinig, Suzanne L.
dc.contributor.authorLovell, Will
dc.contributor.authorRice, Colleen
dc.contributor.authorMitchem, Olivia
dc.contributor.authorBurgess, Dominique
dc.contributor.authorSuggs, Jessica
dc.contributor.authorJacobs, Jordan
dc.contributor.authorWolfgang, Matthew C.
dc.contributor.authorAltinok, Selin
dc.contributor.authorSapoval, Nicolae
dc.contributor.authorTreangen, Todd J.
dc.contributor.authorMoraes-Vieira, Pedro M.
dc.contributor.authorVanderburg, Charles
dc.contributor.authorWallace, Douglas C.
dc.contributor.authorSchisler, Jonathan C.
dc.contributor.authorMason, Christopher E.
dc.contributor.authorChatterjee, Anushree
dc.contributor.authorMeller, Robert
dc.contributor.authorBeheshti, Afshin
dc.date.accessioned2021-10-20T16:31:59Z
dc.date.available2021-10-20T16:31:59Z
dc.date.issued2021
dc.description.abstractMicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we design a miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters, and may potentially inhibit a COVID-19 disease state in humans.
dc.identifier.citationMcDonald, J. Tyson, Enguita, Francisco J., Taylor, Deanne, et al.. "Role of miR-2392 in driving SARS-CoV-2 infection." <i>Cell Reports,</i> 37, no. 3 (2021) Elsevier: https://doi.org/10.1016/j.celrep.2021.109839.
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2021.109839
dc.identifier.urihttps://hdl.handle.net/1911/111580
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordCOVID-19
dc.subject.keywordSARS-CoV-2
dc.subject.keywordmicroRNA
dc.subject.keywordmiRNA
dc.subject.keywordnanoligomers
dc.subject.keywordmiR-2392
dc.subject.keywordantiviral therapeutic
dc.subject.keywordbiomarker
dc.titleRole of miR-2392 in driving SARS-CoV-2 infection
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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