Role of miR-2392 in driving SARS-CoV-2 infection

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dc.citation.articleNumber109839en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleCell Reportsen_US
dc.citation.volumeNumber37en_US
dc.contributor.authorMcDonald, J. Tysonen_US
dc.contributor.authorEnguita, Francisco J.en_US
dc.contributor.authorTaylor, Deanneen_US
dc.contributor.authorGriffin, Robert J.en_US
dc.contributor.authorPriebe, Waldemaren_US
dc.contributor.authorEmmett, Mark R.en_US
dc.contributor.authorSajadi, Mohammad M.en_US
dc.contributor.authorHarris, Anthony D.en_US
dc.contributor.authorClement, Jeanen_US
dc.contributor.authorDybas, Joseph M.en_US
dc.contributor.authorAykin-Burns, Nukheten_US
dc.contributor.authorGuarnieri, Joseph W.en_US
dc.contributor.authorSingh, Larry N.en_US
dc.contributor.authorGrabham, Peteren_US
dc.contributor.authorBaylin, Stephen B.en_US
dc.contributor.authorYousey, Alizaen_US
dc.contributor.authorPearson, Andrea N.en_US
dc.contributor.authorCorry, Peter M.en_US
dc.contributor.authorSaravia-Butler, Amandaen_US
dc.contributor.authorAunins, Thomas R.en_US
dc.contributor.authorSharma, Sadhanaen_US
dc.contributor.authorNagpal, Prashanten_US
dc.contributor.authorMeydan, Cemen_US
dc.contributor.authorFoox, Jonathanen_US
dc.contributor.authorMozsary, Christopheren_US
dc.contributor.authorCerqueira, Biancaen_US
dc.contributor.authorZaksas, Viktorijaen_US
dc.contributor.authorSingh, Urminderen_US
dc.contributor.authorWurtele, Eve Syrkinen_US
dc.contributor.authorCostes, Sylvain V.en_US
dc.contributor.authorDavanzo, Gustavo Gastãoen_US
dc.contributor.authorGaleano, Diegoen_US
dc.contributor.authorPaccanaro, Albertoen_US
dc.contributor.authorMeinig, Suzanne L.en_US
dc.contributor.authorHagan, Robert S.en_US
dc.contributor.authorBowman, Natalie M.en_US
dc.contributor.authorWallet, Shannon M.en_US
dc.contributor.authorMaile, Roberten_US
dc.contributor.authorWolfgang, Matthew C.en_US
dc.contributor.authorHagan, Robert S.en_US
dc.contributor.authorMock, Jason R.en_US
dc.contributor.authorBowman, Natalie M.en_US
dc.contributor.authorTorres-Castillo, Jose L.en_US
dc.contributor.authorLove, Miriya K.en_US
dc.contributor.authorMeinig, Suzanne L.en_US
dc.contributor.authorLovell, Willen_US
dc.contributor.authorRice, Colleenen_US
dc.contributor.authorMitchem, Oliviaen_US
dc.contributor.authorBurgess, Dominiqueen_US
dc.contributor.authorSuggs, Jessicaen_US
dc.contributor.authorJacobs, Jordanen_US
dc.contributor.authorWolfgang, Matthew C.en_US
dc.contributor.authorAltinok, Selinen_US
dc.contributor.authorSapoval, Nicolaeen_US
dc.contributor.authorTreangen, Todd J.en_US
dc.contributor.authorMoraes-Vieira, Pedro M.en_US
dc.contributor.authorVanderburg, Charlesen_US
dc.contributor.authorWallace, Douglas C.en_US
dc.contributor.authorSchisler, Jonathan C.en_US
dc.contributor.authorMason, Christopher E.en_US
dc.contributor.authorChatterjee, Anushreeen_US
dc.contributor.authorMeller, Roberten_US
dc.contributor.authorBeheshti, Afshinen_US
dc.date.accessioned2021-10-20T16:31:59Zen_US
dc.date.available2021-10-20T16:31:59Zen_US
dc.date.issued2021en_US
dc.description.abstractMicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we design a miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters, and may potentially inhibit a COVID-19 disease state in humans.en_US
dc.identifier.citationMcDonald, J. Tyson, Enguita, Francisco J., Taylor, Deanne, et al.. "Role of miR-2392 in driving SARS-CoV-2 infection." <i>Cell Reports,</i> 37, no. 3 (2021) Elsevier: https://doi.org/10.1016/j.celrep.2021.109839.en_US
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2021.109839en_US
dc.identifier.urihttps://hdl.handle.net/1911/111580en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subject.keywordCOVID-19en_US
dc.subject.keywordSARS-CoV-2en_US
dc.subject.keywordmicroRNAen_US
dc.subject.keywordmiRNAen_US
dc.subject.keywordnanoligomersen_US
dc.subject.keywordmiR-2392en_US
dc.subject.keywordantiviral therapeuticen_US
dc.subject.keywordbiomarkeren_US
dc.titleRole of miR-2392 in driving SARS-CoV-2 infectionen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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