Development of a universal, tunable, miniature fluorescence microscope for use at the point of care

Simple item page
dc.citation.firstpage1041en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleBiomedical Optics Expressen_US
dc.citation.lastpage1056en_US
dc.citation.volumeNumber9en_US
dc.contributor.authorWong, Cynthiaen_US
dc.contributor.authorPawlowski, Michal E.en_US
dc.contributor.authorForcucci, Alessandraen_US
dc.contributor.authorMajors, Catherine E.en_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.authorTkaczyk, Tomasz S.en_US
dc.date.accessioned2018-07-16T18:43:46Zen_US
dc.date.available2018-07-16T18:43:46Zen_US
dc.date.issued2018en_US
dc.description.abstractFluorescence microscopy can be a powerful tool for cell-based diagnostic assays; however, imaging can be time consuming and labor intensive to perform. Tunable systems give the ability to electronically focus at user selected depths inside an object volume and may simplify the opto-mechanical design of the imaging system. We present a prototype of a universal, tunable, miniature fluorescence microscope built from poly(methyl methacrylate) singlets that incorporates miniature, electrowetted lenses for electronic focusing. We demonstrate the ability of this system to perform clinically relevant differential white blood cell counts using single use custom cartridges pre-loaded with the fluorescent dye acridine orange.en_US
dc.identifier.citationWong, Cynthia, Pawlowski, Michal E., Forcucci, Alessandra, et al.. "Development of a universal, tunable, miniature fluorescence microscope for use at the point of care." <i>Biomedical Optics Express,</i> 9, no. 3 (2018) The Optical Society: 1041-1056. https://doi.org/10.1364/BOE.9.001041.en_US
dc.identifier.doihttps://doi.org/10.1364/BOE.9.001041en_US
dc.identifier.urihttps://hdl.handle.net/1911/102431en_US
dc.language.isoengen_US
dc.publisherThe Optical Societyen_US
dc.rightsAn OSA-formatted open access journal article PDF may be governed by theﾠOSA Open Access Publishing Agreementﾠsigned by the author and any applicable copyright laws. Authors and readers may use, reuse, and build upon the article, or use it for text or data mining without asking prior permission from the publisher or the Author(s), as long as the purpose is non-commercial and appropriate attribution is maintained.en_US
dc.rights.urihttps://www.osapublishing.org/library/license_v1.cfm#VOR-OAen_US
dc.titleDevelopment of a universal, tunable, miniature fluorescence microscope for use at the point of careen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
boe-9-3-1041.pdf
Size:
5.18 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Bioengineering Publications
ECE Publications