Ultrafast laser surgery probe with a calcium fluoride miniaturized objective for bone ablation

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dc.citation.firstpage4779en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitleBiomedical Optics Expressen_US
dc.citation.lastpage4794en_US
dc.citation.volumeNumber12en_US
dc.contributor.authorSubramanian, Kaushiken_US
dc.contributor.authorSubramanian, Kaushiken_US
dc.contributor.authorAndrus, Liamen_US
dc.contributor.authorAndrus, Liamen_US
dc.contributor.authorPawlowski, Michalen_US
dc.contributor.authorWang, Yeen_US
dc.contributor.authorTkaczyk, Tomaszen_US
dc.contributor.authorBen-Yakar, Adelaen_US
dc.contributor.authorBen-Yakar, Adelaen_US
dc.contributor.authorBen-Yakar, Adelaen_US
dc.date.accessioned2021-07-30T15:21:18Zen_US
dc.date.available2021-07-30T15:21:18Zen_US
dc.date.issued2021en_US
dc.description.abstractWe present a miniaturized ultrafast laser surgery probe with improved miniaturized optics to deliver higher peak powers and enable higher surgical speeds than previously possible. A custom-built miniaturized CaF2 objective showed no evidence of the strong multiphoton absorption observed in our previous ZnS-based probe, enabling higher laser power delivery to the tissue surface for ablation. A Kagome fiber delivered ultrashort pulses from a high repetition rate fiber laser to the objective, producing a focal beam radius of 1.96 μm and covering a 90×90 μm2 scan area. The probe delivered the maximum available fiber laser power, providing fluences >6 J/cm2 at the tissue surface at 53% transmission efficiency. We characterized the probe’s performance through a parametric ablation study on bovine cortical bone and defined optimal operating parameters for surgery using an experimental- and simulation-based approach. The entire opto-mechanical system, enclosed within a 5-mm diameter housing with a 2.6-mm diameter probe tip, achieved material removal rates >0.1 mm3/min, however removal rates were ultimately limited by the available laser power. Towards a next generation surgery probe, we simulated maximum material removal rates when using a higher power fiber laser and found that removal rates >2 mm3/min could be attained through appropriate selection of laser surgery parameters. With future development, the device presented here can serve as a precise surgical tool with clinically viable speeds for delicate applications such as spinal decompression surgeries.en_US
dc.identifier.citationSubramanian, Kaushik, Subramanian, Kaushik, Andrus, Liam, et al.. "Ultrafast laser surgery probe with a calcium fluoride miniaturized objective for bone ablation." <i>Biomedical Optics Express,</i> 12, no. 8 (2021) Optical Society of Americ: 4779-4794. https://doi.org/10.1364/BOE.426149.en_US
dc.identifier.digitalboe-12-8-4779en_US
dc.identifier.doihttps://doi.org/10.1364/BOE.426149en_US
dc.identifier.urihttps://hdl.handle.net/1911/111043en_US
dc.language.isoengen_US
dc.publisherOptical Society of Americen_US
dc.rightsPublished under the terms of the OSA Open Access Publishing Agreementen_US
dc.rights.urihttps://www.osapublishing.org/library/license_v1.cfm#VOR-OAen_US
dc.titleUltrafast laser surgery probe with a calcium fluoride miniaturized objective for bone ablationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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