When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity

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dc.citation.articleNumber104475en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleiScienceen_US
dc.citation.volumeNumber25en_US
dc.contributor.authorZhang, Qingboen_US
dc.contributor.authorHu, Yueen_US
dc.contributor.authorMasterson, Caitlin M.en_US
dc.contributor.authorJang, Wonheeen_US
dc.contributor.authorXiao, Zhenen_US
dc.contributor.authorBohloul, Arashen_US
dc.contributor.authorGarcia-Rojas, Danielen_US
dc.contributor.authorPuppala, Hema L.en_US
dc.contributor.authorBennett, Georgeen_US
dc.contributor.authorColvin, Vicki L.en_US
dc.date.accessioned2022-07-06T18:09:12Zen_US
dc.date.available2022-07-06T18:09:12Zen_US
dc.date.issued2022en_US
dc.description.abstractSilver nanomaterials have potent antibacterial properties that are the foundation for their wide commercial use as well as for concerns about their unintended environmental impact. The nanoparticles themselves are relatively biologically inert but they can undergo oxidative dissolution yielding toxic silver ions. A quantitative relationship between silver material structure and dissolution, and thus antimicrobial activity, has yet to be established. Here, this dissolution process and associated biological activity is characterized using uniform nanoparticles with variable dimension, shape, and surface chemistry. From this, a phenomenological model emerges that quantitatively relates material structure to both silver dissolution and microbial toxicity. Shape has the most profound influence on antibacterial activity, and surprisingly, surface coatings the least. These results illustrate how material structure may be optimized for antimicrobial properties and suggest strategies for minimizing silver nanoparticle effects on microbes.en_US
dc.identifier.citationZhang, Qingbo, Hu, Yue, Masterson, Caitlin M., et al.. "When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity." <i>iScience,</i> 25, no. 7 (2022) Cell Press: https://doi.org/10.1016/j.isci.2022.104475.en_US
dc.identifier.digital1-s2-0-S2589004222007465-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.isci.2022.104475en_US
dc.identifier.urihttps://hdl.handle.net/1911/112670en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.titleWhen function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activityen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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