When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity

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dc.citation.articleNumber104475
dc.citation.issueNumber7
dc.citation.journalTitleiScience
dc.citation.volumeNumber25
dc.contributor.authorZhang, Qingbo
dc.contributor.authorHu, Yue
dc.contributor.authorMasterson, Caitlin M.
dc.contributor.authorJang, Wonhee
dc.contributor.authorXiao, Zhen
dc.contributor.authorBohloul, Arash
dc.contributor.authorGarcia-Rojas, Daniel
dc.contributor.authorPuppala, Hema L.
dc.contributor.authorBennett, George
dc.contributor.authorColvin, Vicki L.
dc.date.accessioned2022-07-06T18:09:12Z
dc.date.available2022-07-06T18:09:12Z
dc.date.issued2022
dc.description.abstractSilver nanomaterials have potent antibacterial properties that are the foundation for their wide commercial use as well as for concerns about their unintended environmental impact. The nanoparticles themselves are relatively biologically inert but they can undergo oxidative dissolution yielding toxic silver ions. A quantitative relationship between silver material structure and dissolution, and thus antimicrobial activity, has yet to be established. Here, this dissolution process and associated biological activity is characterized using uniform nanoparticles with variable dimension, shape, and surface chemistry. From this, a phenomenological model emerges that quantitatively relates material structure to both silver dissolution and microbial toxicity. Shape has the most profound influence on antibacterial activity, and surprisingly, surface coatings the least. These results illustrate how material structure may be optimized for antimicrobial properties and suggest strategies for minimizing silver nanoparticle effects on microbes.
dc.identifier.citationZhang, Qingbo, Hu, Yue, Masterson, Caitlin M., et al.. "When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity." <i>iScience,</i> 25, no. 7 (2022) Cell Press: https://doi.org/10.1016/j.isci.2022.104475.
dc.identifier.digital1-s2-0-S2589004222007465-main
dc.identifier.doihttps://doi.org/10.1016/j.isci.2022.104475
dc.identifier.urihttps://hdl.handle.net/1911/112670
dc.language.isoeng
dc.publisherCell Press
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.titleWhen function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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