Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules

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dc.citation.firstpagee0131643en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitlePLoS ONEen_US
dc.citation.volumeNumber10en_US
dc.contributor.authorHsu, Chih-Weien_US
dc.contributor.authorPoché, Ross A.en_US
dc.contributor.authorSaik, Jennifer E.en_US
dc.contributor.authorAli, Saniyaen_US
dc.contributor.authorWang, Shangen_US
dc.contributor.authorYosef, Nejlaen_US
dc.contributor.authorCalderon, Gisele A.en_US
dc.contributor.authorScott, Larry Jr.en_US
dc.contributor.authorVadakkan, Tegy J.en_US
dc.contributor.authorLarina, Irina V.en_US
dc.contributor.authorWest, Jennifer L.en_US
dc.contributor.authorDickinson, Mary E.en_US
dc.date.accessioned2016-04-01T20:24:37Zen_US
dc.date.available2016-04-01T20:24:37Zen_US
dc.date.issued2015en_US
dc.description.abstractSuccessful engineering of complex organs requires improved methods to promote rapid and stable vascularization of artificial tissue scaffolds. Toward this goal, tissue engineering strategies utilize the release of pro-angiogenic growth factors, alone or in combination, from biomaterials to induce angiogenesis. In this study we have used intravital microscopy to define key, dynamic cellular changes induced by the release of pro-angiogenic factors from polyethylene glycol diacrylate hydrogels transplanted in vivo. Our data show robust macrophage recruitment when the potent and synergistic angiogenic factors, PDGFBB and FGF2 were used as compared with VEGF alone and intravital imaging suggested roles for macrophages in endothelial tip cell migration and anastomosis, as well as pericyte-like behavior. Further data from in vivo experiments show that delivery of CSF1 with VEGF can dramatically improve the poor angiogenic response seen with VEGF alone. These studies show that incorporating macrophage-recruiting factors into the design of pro-angiogenic biomaterial scaffolds is a key strategy likely to be necessary for stable vascularization and survival of implanted artificial tissues.en_US
dc.identifier.citationHsu, Chih-Wei, Poché, Ross A., Saik, Jennifer E., et al.. "Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules." <i>PLoS ONE,</i> 10, no. 7 (2015) Public Library of Science: e0131643. http://dx.doi.org/10.1371/journal.pone.0131643.en_US
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0131643en_US
dc.identifier.urihttps://hdl.handle.net/1911/88821en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleImproved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Moleculesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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