Potential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans

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dc.citation.firstpage1469
dc.citation.issueNumber3
dc.citation.journalTitleGenetics
dc.citation.lastpage1478
dc.citation.volumeNumber206
dc.contributor.authorZhou, Ying
dc.contributor.authorLoeza-Cabrera, Mario
dc.contributor.authorLiu, Zheng
dc.contributor.authorAleman-Meza, Boanerges
dc.contributor.authorNguyen, Julie K.
dc.contributor.authorJung, Sang-Kyu
dc.contributor.authorChoi, Yuna
dc.contributor.authorShou, Qingyao
dc.contributor.authorButcher, Rebecca A.
dc.contributor.authorZhong, Weiwei
dc.date.accessioned2017-11-14T18:08:24Z
dc.date.available2017-11-14T18:08:24Z
dc.date.issued2017
dc.description.abstractIt is crucial for animal survival to detect dangers such as predators. A good indicator of dangers is injury of conspecifics. Here we show that fluids released from injured conspecifics invoke acute avoidance in both free-living and parasitic nematodes. Caenorhabditis elegans avoids extracts from closely related nematode species but not fruit fly larvae. The worm extracts have no impact on animal lifespan, suggesting that the worm extract may function as an alarm instead of inflicting physical harm. Avoidance of the worm extract requires the function of a cGMP signaling pathway that includes the cGMP-gated channel TAX-2/TAX-4 in the amphid sensory neurons ASI and ASK. Genetic evidence indicates that the avoidance behavior is modulated by the neurotransmitters GABA and serotonin, two common targets of anxiolytic drugs. Together, these data support a model that nematodes use a nematode-specific alarm pheromone to detect conspecific injury.
dc.identifier.citationZhou, Ying, Loeza-Cabrera, Mario, Liu, Zheng, et al.. "Potential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans." <i>Genetics,</i> 206, no. 3 (2017) Genetics Society of America: 1469-1478. https://doi.org/10.1534/genetics.116.197293.
dc.identifier.digitalgenetics.116.197293.full
dc.identifier.doihttps://doi.org/10.1534/genetics.116.197293
dc.identifier.urihttps://hdl.handle.net/1911/98809
dc.language.isoeng
dc.publisherGenetics Society of America
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Genetics Society of America.
dc.subject.keywordCaenorhabditis elegans
dc.subject.keywordchemotaxis
dc.subject.keywordolfactory
dc.subject.keywordpheromone
dc.titlePotential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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