Potential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans

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dc.citation.firstpage1469en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleGeneticsen_US
dc.citation.lastpage1478en_US
dc.citation.volumeNumber206en_US
dc.contributor.authorZhou, Yingen_US
dc.contributor.authorLoeza-Cabrera, Marioen_US
dc.contributor.authorLiu, Zhengen_US
dc.contributor.authorAleman-Meza, Boanergesen_US
dc.contributor.authorNguyen, Julie K.en_US
dc.contributor.authorJung, Sang-Kyuen_US
dc.contributor.authorChoi, Yunaen_US
dc.contributor.authorShou, Qingyaoen_US
dc.contributor.authorButcher, Rebecca A.en_US
dc.contributor.authorZhong, Weiweien_US
dc.date.accessioned2017-11-14T18:08:24Zen_US
dc.date.available2017-11-14T18:08:24Zen_US
dc.date.issued2017en_US
dc.description.abstractIt is crucial for animal survival to detect dangers such as predators. A good indicator of dangers is injury of conspecifics. Here we show that fluids released from injured conspecifics invoke acute avoidance in both free-living and parasitic nematodes. Caenorhabditis elegans avoids extracts from closely related nematode species but not fruit fly larvae. The worm extracts have no impact on animal lifespan, suggesting that the worm extract may function as an alarm instead of inflicting physical harm. Avoidance of the worm extract requires the function of a cGMP signaling pathway that includes the cGMP-gated channel TAX-2/TAX-4 in the amphid sensory neurons ASI and ASK. Genetic evidence indicates that the avoidance behavior is modulated by the neurotransmitters GABA and serotonin, two common targets of anxiolytic drugs. Together, these data support a model that nematodes use a nematode-specific alarm pheromone to detect conspecific injury.en_US
dc.identifier.citationZhou, Ying, Loeza-Cabrera, Mario, Liu, Zheng, et al.. "Potential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans." <i>Genetics,</i> 206, no. 3 (2017) Genetics Society of America: 1469-1478. https://doi.org/10.1534/genetics.116.197293.en_US
dc.identifier.digitalgenetics.116.197293.fullen_US
dc.identifier.doihttps://doi.org/10.1534/genetics.116.197293en_US
dc.identifier.urihttps://hdl.handle.net/1911/98809en_US
dc.language.isoengen_US
dc.publisherGenetics Society of Americaen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Genetics Society of America.en_US
dc.subject.keywordCaenorhabditis elegansen_US
dc.subject.keywordchemotaxisen_US
dc.subject.keywordolfactoryen_US
dc.subject.keywordpheromoneen_US
dc.titlePotential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegansen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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