Integrating DNA strand-displacement circuitry with DNA tile self-assembly
dc.citation.journalTitle | Nature Communications | |
dc.citation.volumeNumber | 4 | |
dc.contributor.author | Zhang, David Yu | |
dc.contributor.author | Hariadi, Rizal F. | |
dc.contributor.author | Choi, Harry M.T. | |
dc.contributor.author | Winfree, Erik | |
dc.date.accessioned | 2016-02-02T21:22:53Z | |
dc.date.available | 2016-02-02T21:22:53Z | |
dc.date.issued | 2013 | |
dc.description.abstract | DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures. | |
dc.identifier.citation | Zhang, David Yu, Hariadi, Rizal F., Choi, Harry M.T., et al.. "Integrating DNA strand-displacement circuitry with DNA tile self-assembly." <i>Nature Communications,</i> 4, (2013) Macmillan Publishers Limited: http://dx.doi.org/10.1038/ncomms2965. | |
dc.identifier.doi | http://dx.doi.org/10.1038/ncomms2965 | |
dc.identifier.uri | https://hdl.handle.net/1911/88317 | |
dc.language.iso | eng | |
dc.publisher | Macmillan Publishers Limited | |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.title | Integrating DNA strand-displacement circuitry with DNA tile self-assembly | |
dc.type | Journal article | |
dc.type.dcmi | Text | |
dc.type.publication | publisher version |
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