Integrating DNA strand-displacement circuitry with DNA tile self-assembly

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dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber4en_US
dc.contributor.authorZhang, David Yuen_US
dc.contributor.authorHariadi, Rizal F.en_US
dc.contributor.authorChoi, Harry M.T.en_US
dc.contributor.authorWinfree, Eriken_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2016-02-02T21:22:53Zen_US
dc.date.available2016-02-02T21:22:53Zen_US
dc.date.issued2013en_US
dc.description.abstractDNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures.en_US
dc.identifier.citationZhang, David Yu, Hariadi, Rizal F., Choi, Harry M.T., et al.. "Integrating DNA strand-displacement circuitry with DNA tile self-assembly." <i>Nature Communications,</i> 4, (2013) Macmillan Publishers Limited: http://dx.doi.org/10.1038/ncomms2965.en_US
dc.identifier.doihttp://dx.doi.org/10.1038/ncomms2965en_US
dc.identifier.urihttps://hdl.handle.net/1911/88317en_US
dc.language.isoengen_US
dc.publisherMacmillan Publishers Limiteden_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.titleIntegrating DNA strand-displacement circuitry with DNA tile self-assemblyen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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