Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats

Simple item page
dc.citation.articleNumber75en_US
dc.citation.journalTitleSurgical Neurology Internationalen_US
dc.citation.volumeNumber7en_US
dc.contributor.authorPalejwala, Ali H.en_US
dc.contributor.authorFridley, Jared S.en_US
dc.contributor.authorMata, Javier A.en_US
dc.contributor.authorSamuel, Errol L.G.en_US
dc.contributor.authorLuerssen, Thomas G.en_US
dc.contributor.authorPerlaky, Laszloen_US
dc.contributor.authorKent, Thomas A.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.authorJea, Andrewen_US
dc.date.accessioned2016-12-07T18:50:38Zen_US
dc.date.available2016-12-07T18:50:38Zen_US
dc.date.issued2016en_US
dc.description.abstractBackground: Graphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible in vitro; in the present study, we wished to evaluate its biocompatibility in an in vivo spinal cord injury model. Methods: Graphene nanoscaffolds were prepared by the mild chemical reduction of graphene oxide. Twenty Wistar rats (19 male and 1 female) underwent hemispinal cord transection at approximately the T2 level. To bridge the lesion, graphene nanoscaffolds with a hydrogel were implanted immediately after spinal cord transection. Control animals were treated with hydrogel matrix alone. Histologic evaluation was performed 3 months after the spinal cord transection to assess in vivo biocompatibility of graphene and to measure the ingrowth of tissue elements adjacent to the graphene nanoscaffold. Results: The graphene nanoscaffolds adhered well to the spinal cord tissue. There was no area of pseudocyst around the scaffolds suggestive of cytotoxicity. Instead, histological evaluation showed an ingrowth of connective tissue elements, blood vessels, neurofilaments, and Schwann cells around the graphene nanoscaffolds. Conclusions: Graphene is a nanomaterial that is biocompatible with neurons and may have significant biomedical application. It may provide a scaffold for the ingrowth of regenerating axons after spinal cord injury.en_US
dc.identifier.citationPalejwala, Ali H., Fridley, Jared S., Mata, Javier A., et al.. "Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats." <i>Surgical Neurology International,</i> 7, (2016) Surgical Neurology International: http://dx.doi.org/10.4103/2152-7806.188905.en_US
dc.identifier.doihttp://dx.doi.org/10.4103/2152-7806.188905en_US
dc.identifier.urihttps://hdl.handle.net/1911/92739en_US
dc.language.isoengen_US
dc.publisherSurgical Neurology Internationalen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/us/en_US
dc.subject.keywordbiocompatibilityen_US
dc.subject.keywordcytotoxicityen_US
dc.subject.keywordgrapheneen_US
dc.subject.keywordnanomedicineen_US
dc.subject.keywordneuronen_US
dc.subject.keywordspinal cord injuryen_US
dc.titleBiocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in ratsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Biocompatibility.pdf
Size:
4.24 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Chemistry Publications
Materials Science and NanoEngineering Publications